- Synthesis of well-defined photo-cross-linked polymeric nanocapsules by surface-initiated raft polymerization
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Narrowly distributed hollow polymeric nanocapsules (PtBMA-co-PDMIPM-b- PHPMA), with the size of 450 or 900 nm, were first synthesized by surface-initiated reversible addition-fragmentation chain transfer (RAFT) polymerization exploiting silica nanoparticl
- Huang, Xin,Appelhans, Dietmar,Formanek, Petr,Simon, Frank,Voit, Brigitte
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- PEPTIDE-BASED VACCINES, METHODS OF MANUFACTURING, AND USES THEREOF FOR INDUCING AN IMMUNE RESPONSE
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The present disclosure relates to novel peptide-based vaccines, methods of manufacturing the novel peptide-based vaccines and uses thereof for delivering peptide antigens to induce an immune response, and in particular a T cell response to a subject.
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Paragraph 0494
(2020/03/01)
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- COMPOSITIONS AND METHODS OF MANUFACTURING STAR POLYMERS FOR LIGAND DISPLAY AND/OR DRUG DELIVERY
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A star polymer of formula O[P1]-([X]-A[P2]-[Z]-[P3])n where O is a core; A is a polymer arm attached to the core; X is a linker molecule between the core and the polymer arm; Z is a linker molecule between the end of the polymer arm and P3; P1, P2 and P3 are each independently one or more pharmaceutically active compounds that act extracellularly or intracellularly, n is an integer number; [ ] denotes that the group is optional; and at least one of P1, P2 or P3 is present.
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Paragraph 00451-00453
(2020/10/28)
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- Non-covalent hitchhiking on endogenous carriers as a protraction mechanism for antiviral macromolecular prodrugs
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Albumin is a highly successful tool of drug delivery providing drastically extended body and blood residence time for the associated cargo, but it only traffics single drug copies at a time. In turn, macromolecular prodrugs (MP) are advantaged in carrying
- Frich, Camilla Kaas,Krüger, Franziska,Walther, Raoul,Domar, Cecilie,Andersen, Anna H.F.,Tvilum, Anne,Dagn?s-Hansen, Frederik,Denton, Paul W.,Tolstrup, Martin,Paludan, S?ren R.,Münch, Jan,Zelikin, Alexander N.
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p. 298 - 310
(2019/01/03)
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- ANTIBODY-POLYMER-DRUG CONJUGATES
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Disclosed herein, are antibody-polymer-drug conjugates. The conjugate comprises a targeting moiety, one or more polymers, and one or more therapeutic agents. Also described herein, are compositions comprising the conjugates, methods of their preparation,
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Page/Page column 42-43; 4
(2018/04/27)
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- Synthesis of well-defined semitelechelic poly[N-(2-hydroxypropyl) methacrylamide] polymers with functional group at the α-end of the polymer chain by RAFT polymerization
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N-(2-Hydroxypropyl)methacrylamide polymer precursors (pHPMA) with very narrow distribution of molecular weights and polymer chain terminating in a single reactive group have big potential in the synthesis of various polymer drug and gene delivery systems. This paper shows that pHPMA can be prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization; the pHPMAs prepared by RAFT polymerization conducted to high conversions contained at the α-end of the polymer chain a single functional group originated from both, the chain transfer agent (CTA) and initiator (INI) in ratio depending on polymerization conditions. The well-defined monofunctional pHPMAs with narrow molecular weight distribution and with single reactive group situated at the α-polymer chain end can be prepared in one step by RAFT polymerization initiated by the tailor-made CTA and INI, both containing the same functional group in their structure. Synthesis of pHPMAs terminating in various reactive groups (azide, propargyl, thiazolidin-2-thione, amino, hydrazide) was also described.
- Subr,Kostka,Strohalm,Etrych,Ulbrich
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p. 2100 - 2108
(2013/05/22)
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- Synthesis and bioactivity of poly(HPMA)-lysozyme conjugates: The use of novel thiazolidine-2-thione coupling chemistry
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A novel thiazolidine-2-thione functionalized chain transfer agent (CTA) was synthesized and used as a reversible addition-fragmentation chain transfer (RAFT) polymerization agent to prepare well-defined poly-N-(2-hydroxypropyl) methacrylamide (PHPMA). The
- Tao, Lei,Liu, Jingquan,Xu, Jiangtao,Davis, Thomas P.
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experimental part
p. 3481 - 3485
(2010/01/06)
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