887764-14-9

Upstream product

• 134469-06-0 thiazolidine-2-thione 
• 201611-92-9 4-cyano-4-(thiobenzoylthio)pentanoic acid 
• 5873-93-8 bis(thiobenzoyl) disulfide 
• 870779-03-6 2-[1-cyano-1-methyl-4-oxo-4-(2-thioxo-thiazolidin-3-yl)-butylazo]-2-methyl-5-oxo-5-(2-thioxothiazolidin-3-yl)-pentanenitrile 

Downstream Products

• 1202708-43-7 C₂₃H₂₈Br₂N₂O₅S₂ 
• 1186665-00-8 5-(bis(2-hydroxyethyl)amino)-2-cyano-5-oxopentan-2-yl benzodithioate 
• 1259437-57-4 2-(4-cyano-4-((phenylcarbonothioyl)thio)pentanamido)ethyl 4-(pyren-1-yl)butanoate 

Relevant academic research and scientific papers

Synthesis of well-defined photo-cross-linked polymeric nanocapsules by surface-initiated raft polymerization

Narrowly distributed hollow polymeric nanocapsules (PtBMA-co-PDMIPM-b- PHPMA), with the size of 450 or 900 nm, were first synthesized by surface-initiated reversible addition-fragmentation chain transfer (RAFT) polymerization exploiting silica nanoparticl

PEPTIDE-BASED VACCINES, METHODS OF MANUFACTURING, AND USES THEREOF FOR INDUCING AN IMMUNE RESPONSE

The present disclosure relates to novel peptide-based vaccines, methods of manufacturing the novel peptide-based vaccines and uses thereof for delivering peptide antigens to induce an immune response, and in particular a T cell response to a subject.

COMPOSITIONS AND METHODS OF MANUFACTURING STAR POLYMERS FOR LIGAND DISPLAY AND/OR DRUG DELIVERY

A star polymer of formula O[P1]-([X]-A[P2]-[Z]-[P3])n where O is a core; A is a polymer arm attached to the core; X is a linker molecule between the core and the polymer arm; Z is a linker molecule between the end of the polymer arm and P3; P1, P2 and P3 are each independently one or more pharmaceutically active compounds that act extracellularly or intracellularly, n is an integer number; [ ] denotes that the group is optional; and at least one of P1, P2 or P3 is present.

Non-covalent hitchhiking on endogenous carriers as a protraction mechanism for antiviral macromolecular prodrugs

Albumin is a highly successful tool of drug delivery providing drastically extended body and blood residence time for the associated cargo, but it only traffics single drug copies at a time. In turn, macromolecular prodrugs (MP) are advantaged in carrying

ANTIBODY-POLYMER-DRUG CONJUGATES

Disclosed herein, are antibody-polymer-drug conjugates. The conjugate comprises a targeting moiety, one or more polymers, and one or more therapeutic agents. Also described herein, are compositions comprising the conjugates, methods of their preparation,

Synthesis of well-defined semitelechelic poly[N-(2-hydroxypropyl) methacrylamide] polymers with functional group at the α-end of the polymer chain by RAFT polymerization

N-(2-Hydroxypropyl)methacrylamide polymer precursors (pHPMA) with very narrow distribution of molecular weights and polymer chain terminating in a single reactive group have big potential in the synthesis of various polymer drug and gene delivery systems. This paper shows that pHPMA can be prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization; the pHPMAs prepared by RAFT polymerization conducted to high conversions contained at the α-end of the polymer chain a single functional group originated from both, the chain transfer agent (CTA) and initiator (INI) in ratio depending on polymerization conditions. The well-defined monofunctional pHPMAs with narrow molecular weight distribution and with single reactive group situated at the α-polymer chain end can be prepared in one step by RAFT polymerization initiated by the tailor-made CTA and INI, both containing the same functional group in their structure. Synthesis of pHPMAs terminating in various reactive groups (azide, propargyl, thiazolidin-2-thione, amino, hydrazide) was also described.

Synthesis and bioactivity of poly(HPMA)-lysozyme conjugates: The use of novel thiazolidine-2-thione coupling chemistry

A novel thiazolidine-2-thione functionalized chain transfer agent (CTA) was synthesized and used as a reversible addition-fragmentation chain transfer (RAFT) polymerization agent to prepare well-defined poly-N-(2-hydroxypropyl) methacrylamide (PHPMA). The