Coupling Reaction between Aldehydes and Non-Activated Hydrocarbons via the Reductive Radical-Polar Crossover Pathway
Herein, we describe the generation of an organochromium-type carbanion species from a non-activated C-H bond and its nucleophilic addition to aldehydes. The catalytic carbanion generation occurred through formal deprotonation of a non-activated C-H bond under mild conditions and did not need the prefunctionalization or anion stabilizing group. Carbon radical intermediates generated by decatungstate photocatalyst-mediated hydrogen abstraction were captured by a chromium salt with the reductive radical-polar crossover reaction to produce organochromium carbanions.
Neighbour Group Participation with Reductions and Hydride Abstractions
The reduction of N-(2-hydroxyalkyl)lactams with diisobutylaluminium hydride and the hydride ion abstraction of the corresponding amino alcohols give under neighbour group participation the fused oxazolidines.
Moehre, H.,Kamper, Ch.
p. 512 - 520
(2007/10/02)
α-Substitution of Amines via Dipole Stabilized Carbanions from Formamidines
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Meyers, A. I.,Hoeve, Wolter Ten
p. 7125 - 7126
(2007/10/02)
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