889673-94-3

Basic information

• Product Name: Acetamide, N-(3-oxo-1-phenyl-1-propenyl)- (9CI)
• Synonyms: Acetamide, N-(3-oxo-1-phenyl-1-propenyl)- (9CI)
• CAS NO: 889673-94-3
• Molecular Formula: C11H11NO2
• Molecular Weight: 0
• Mol File: 889673-94-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Acetamide, N-(3-oxo-1-phenyl-1-propenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-(3-oxo-1-phenyl-1-propenyl)- (9CI)(889673-94-3)
• EPA Substance Registry System: Acetamide, N-(3-oxo-1-phenyl-1-propenyl)- (9CI)(889673-94-3)

Safety Data

• Hazardous Substances Data: 889673-94-3(Hazardous Substances Data)

Upstream product

• 57957-24-1 N-(1-phenylvinyl)acetamide 
• 3724-43-4 Vilsmeier reagent 
• 613-91-2 acetophenone oxime 
• 68-12-2 N,N-dimethyl-formamide 
• 98-86-2 acetophenone 

Relevant articles and documents

Synthesis of D-Ring Annulated Pyridosteroids from β-Formyl Enamides and Their Biological Evaluations

Herein, we report the synthesis of a novel class of substituted androst[17,16-b]pyridines (pyridosteroids) from the reaction of β-formyl enamides with alkynes in high yields. The optimized reaction protocol was extended to acyclic and cyclic β-formyl enamides to afford nonsteroidal pyridines. Cell survival assay of all compounds were carried against prostate cancer PC-3 cells wherein 3-hydroxy-5-en-2′,3′-dicarbethoxy-androst[17,16-b]pyridine showed the highest cytotoxic activity. Phase contrast microscopy and flow cytometry studies exhibited marked morphological features characteristic of apoptosis in 3-hydroxy-5-en-2′,3′-dicarbethoxy-androst[17,16-b]pyridine and abiraterone treated PC-3 cells. The treatment of 3-hydroxy-5-en-2′,3′-dicarbethoxy-androst[17,16-b]pyridine induces G2/M phase cell cycle arrest in prostate cancer PC-3 cells. Enhancement of apoptotic inductions of PC-3 cells by 3-hydroxy-5-en-2′,3′-dicarbethoxy-androst[17,16-b]pyridine and abiraterone through the activation of caspases-6, -7, and -8 pathways were supported by qRT-PCR. In silico study of the compound 3-hydroxy-5-en-2′,3′-dicarbethoxy-androst[17,16-b]pyridine showed stable and promising interaction with the key caspase proteins. Our studies revealed that the pyridosteroid 3-hydroxy-5-en-2′,3′-dicarbethoxy-androst[17,16-b]pyridine, bearing pyridine-2,3-dicarbethoxy pharmacophore, facilitated initiation of caspase-8 and activates downstream effectors caspase-6 and caspase-7 and thereby triggering apoptosis of PC-3 cancer cells.

PROCESS FOR THE PREPARATION OF N-ACYL BETA-AMINOALDEHYDES

This invention relates to a process for the preparation of enantiomerically enriched N--acyl ?-aminoaldehydes. In particular it relates to asymmetric hydrogenation of N-acyl enamides.