- Aromatic ring liquid crystal compound and liquid crystal composition and application thereof
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The invention relates to an aromatic ring liquid crystal compound, a liquid crystal composition and an assembly suitable for a microwave region and a millimeter wave region of a high-frequency technology or an electromagnetic spectrum, and particularly a phase shifter and a microwave array antenna. The liquid crystal composition provided by the invention at least comprises a compound represented by a general formula I. The liquid crystal composition provided by the invention is good in stability, high in response speed and wide in liquid crystal phase temperature range.
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Paragraph 0116-0118; 0123-0124; 0147-0149; 0152-0153
(2021/05/29)
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- A two price arrowheads catalytic 4 - methyl - 2 - nitroaniline synthetic method (by machine translation)
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The invention discloses a method for synthesizing 4 - methyl - 2 - nitroaniline method, comprises the following steps: (1) in order to N - (toluene) urethane raw material, addition of an oxidizing agent, to palladium acetate, palladium chloride and palladium sulfate in an arbitrary as catalyst, as the nitrating agent is tert-butyl nitrite, in the 80 - 100 °C lower, in solvent 1, 4 - dioxane are reacted in a, make corresponding O-nitro containing protecting group to the toluidine; (2) then hydrolysis, to obtain the target product. 2. Method according to Claim 1, characterized in that part (1) in the step, the oxidant is air, O2 And hydrogen peroxide in an arbitrary. The method of the invention preparation technology is simple, mild reaction conditions, high yield, environment-friendly. (by machine translation)
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Paragraph 0020-0023; 0024-0027; 0028-0031; 0032-0035
(2018/04/27)
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- 4-methyl-2-nitroaniline synthesis method
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The invention discloses a 4-methyl-2-nitroaniline synthesis method, which comprises: carrying out amino protection with ethyl chloroformate by using 4-methylaniline as a raw material to generate N-(p-toluene)ethyl carbamate; adding an oxidant and a copper salt catalyst, and carrying out a reaction for a certain time at a temperature of 50-120 DEG C in a reaction solvent by using a nitroso-containing compound as a nitrating agent to prepare a corresponding protected o-nitro-p-toluidine; and carrying out hydrolysis to obtain the target product. According to the present invention, the method hasadvantages of simple preparation process, mild reaction condition, high yield and environment protection.
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Paragraph 0018-0028
(2018/03/24)
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- Selectivity of the complexation reactions of four regioisomeric methylcamphorquinoxaline ligands with gold(III): X-ray, NMR and DFT investigations
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Reported are the synthesis, spectral and structural characteristics of new quinoxaline-related regioisomeric ligands L1-L4 (1,x,11,11-tetramethyl-1,2,3,4-tetrahydro-1,4-methanophenazine, x = 7, 8, 9 and 6, respectively) and their mononuclear Au(III) complexes (1-4). Fusion of the camphor moiety to the quinoxaline core made two N-atoms of quinoxaline nonequivalent while the introduction of a methyl-substituent at positions 6-9 enabled a tuning of coordination properties of L1-L4. Gold(III) complexes 1-4 and ligands L1-L4 have been studied in detailed by 1D and 2D NMR and the structures of 1-4 have been determined by X-ray crystallography. The results of these analyses revealed a regiospecific coordination of Au(III) to the sterically less hindered N-5 atom (spatially close to the non-substituted bridgehead carbon) of L1-L3, and to N-10 (spatially close to the methyl-substituted bridgehead carbon) of L4. The results of DFT calculations shed light on disparate coordination modes of L1-L4 toward the AuCl3 fragment and explain formation of single coordination products in high yield.
- Gli?i?, Biljana D.,Hoffmann, Marcin,Warzajtis, Beata,Gen?i?, Marija S.,Blagojevi?, Polina D.,Radulovi?, Niko S.,Rychlewska, Urszula,Djuran, Milo? I.
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p. 137 - 149
(2016/01/15)
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- Perenosins: A new class of anion transporter with anti-cancer activity
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A new class of anion transporter named 'perenosins' consisting of a pyrrole linked through an imine to either an indole, benzimidazole or indazole is reported. The indole containing members of the perenosin family function as effective transmembrane Cl-/NO3- antiporters and HCl cotransporters in a manner similar to the prodigiosenes. The compounds reduce the viability of MDA-MB-231 and MCF-7.
- Van Rossom, Wim,Asby, Daniel J.,Tavassoli, Ali,Gale, Philip A.
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p. 2645 - 2650
(2016/03/05)
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- Discovery of phenoxybutanoic acid derivatives as potent endothelin antagonists with antihypertensive activity
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A series of phenoxybutanoic acid derivatives were synthesized and tested for their antagonistic activity on the contraction of the rat thoracic aortic ring induced by endothelin-1. Preliminary screening results showed that 6e and 6g with benzoheterocycles demonstrated significant antagonistic activities when compared to the reference compound BQ123. The results from additional assays for the binding affinity and selectivity for endothelin receptors showed that 6e was a selective ETA antagonist with a nanomolar IC50. Moreover, 6e was effective in relieving hypoxia-induced pulmonary arterial hypertension and right ventricular weight ratio. Therefore, 6e may have potential for further development as a therapeutic agent for the treatment of cardiovascular diseases.
- Cai, Jin,Liu, Ligang,Hong, Kwon Ho,Wang, Peng,Li, Lushen,Cao, Meng,Sun, Chunlong,Wu, Xiaoqing,Zong, Xi,Chen, Junqing,Ji, Min
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p. 657 - 667
(2015/02/19)
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- Direct oxidative nitration of aromatic sulfonamides under mild conditions
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A direct nitration of aromatic sulfonamides using sodium nitrite as the nitrating agent has been developed. The reaction shows typically mono-substitution selectivity and can be enlarged to the gram scale with good yield.
- Li, Ying-Xiu,Li, Lian-Hua,Yang, Yan-Fang,Hua, Hui-Liang,Yan, Xiao-Biao,Zhao, Lian-Biao,Zhang, Jin-Bang,Ji, Fa-Jin,Liang, Yong-Min
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supporting information
p. 9936 - 9938
(2014/08/18)
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- Copper-catalyzed mild nitration of protected anilines
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A practical copper-catalyzed direct nitration of protected anilines, by using one equivalent of nitric acid as the nitrating agent, has been developed. This procedure features mild reaction conditions, wide structural scope (with regard to both N-protecting group and arene substitution), and high functional-group tolerance. Dinitration with two equivalents of nitric acid is also feasible. Practical and reliable: A Cu-catalyzed selective nitration of para- and ortho-substituted aniline derivatives by using one equivalent of HNO3 has been developed that produces water as the only stoichiometric byproduct (see scheme; PG=protecting group). This method is compatible with strongly electron-deficient substrates, enabling dinitration (by using 2.0 equiv of HNO3). This method allows for a rapid access to relevant nitrogen-containing heterocyclic architectures.
- Hernando, Elier,Castillo, Rafael R.,Rodríguez, Nuria,G?mez Arrayás, Ram?n,Carretero, Juan C.
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p. 13854 - 13859
(2016/02/18)
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- Design of ionic liquid 3-methyl-1-sulfonic acid imidazolium nitrate as reagent for the nitration of aromatic compounds by in situ generation of NO 2 in acidic media
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3-Methyl-1-sulfonic acid imidazolium nitrate ([Msim]NO3) as a new Bronsted acidic ionic liquid and nitrating agent was prepared and used for the efficient nitration of aromatic compounds (even aniline derivatives). The dramatic effect of this reagent by in situ generation of nitrogen dioxide as a radical on aromatic compounds to give nitroarenes has been studied.
- Zolfigol, Mohammad A.,Khazaei, Ardeshir,Moosavi-Zare, Ahmad R.,Zare, Abdolkarim,Kruger, Hendrik G.,Asgari, Zhila,Khakyzadeh, Vahid,Kazem-Rostami, Masoud
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experimental part
p. 3640 - 3645
(2012/06/15)
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- Arylethenylbenzofuroxan derivatives as drugs for chagas disease: Multigram batch synthesis ysubg a wuttug#bideb process
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In the present work, we developed robust processes for the preparation of new antitrypanosomal benzofuroxans, E and Z isomers of 5-arylethenylbenzo[1,2-c] 1,2,5-oxadiazole p1N-oxide 1-6, in muhigram batch through Wittig-Boden conditions as the key synthetic step. In these conditions, the generation of the benzofurazans, as secondary byproduct, was minimized.
- Porcal, Williams,Merlino, Alicia,Boiani, Mariana,Gerpe, Alejandra,Gonzalez, Mercedes,Cerecetto, Hugo
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supporting information
p. 156 - 162
(2013/01/03)
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- Syntheses of 4-methoxymethylbenzyl permethrinates containing fluorine and their insecticidal activity
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In order to investigate the relationship between the position of fluorine atom and insecticidal activity about 4-methoxymethylbenzyl permethrinates containing fluorine, 2 and 3-fluoro-4-methoxymethylbenzyl (±)-cis-permethrinate were synthesized. Their insecticidal activities were tested and the fluorine effect of title compounds was discussed.
- Zou, Xinzhuo,Qiu, Zongxing
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p. 173 - 179
(2007/10/03)
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- Nitroanilines are the reduction products of benzofuroxan system by oxyhemoglobin (HbO22+)
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Benzofuroxans are interesting compounds which display several biochemical and pharmacological properties. Recent studies from our laboratory demonstrate that they are reduced by ferrous salts at room temperature and that the principal reaction products are o-nitroanilines. This paper shows that simple benzofuroxan derivatives are also able to oxidise HbO22+ to methemoglobin (MetHb3+) (UV detection) and to form o-nitroanilines (HPLC detection). From a toxicological point of view this reaction is interesting, since it indicates that the blood is a site for metabolism of these compounds with consequent methemoglobinemia and formation of toxic compounds.
- Medana, Claudio,Visentin, Sonja,Grosa, Giorgio,Fruttero, Roberta,Gasco, Alberto
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p. 799 - 802
(2007/10/03)
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- Hypoxia-Selective Agents Derived from Quinoxaline 1,4-Di-N-oxides
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Hypoxic cells, which are a common feature of solid tumors, but not normal tissues, are resistant to both anticancer drugs and radiation therapy.Thus the identification of drugs with selective toxicity toward hypoxic cells is an important objective in anticancer chemotherapy.The benzotriazine di-N-oxide (SR 4233, Tirapazamine) has been shown to be an efficient and selective cytotoxin for hypoxic cells.Since the bioreductive activation of Tirapazamine is thought to be due to the presence of the 1,4-di-N-oxide moiety, a series of 3-aminoquinoxaline-2-carbonitrile 1,4-di-N-oxides with a range of electron-donating and -withdrawing substituents in the 6- and /or 7- positions has been synthesized and evaluated for toxicity to hypoxic cells.Electrochemical studies of the quinoxaline di-N-oxides and Tirapazamine showed that as the electron-withdrawing nature of the 6(7)-substituent increases, the reduction potential becomes more positive and the compound is more readily reduced.Apart from the unsubstituted 6a and the 6,7-dimethyl derivative 6c, the quinoxaline di-N-oxide have reduction potentials significantly more positive than Tirapazamine (Epc -0.90 V).The most potent cytotoxins to cells in culture were the 6,7-dichloro and 6,7-difluoro derivatives 6i and 6l, which were 30-fold more potent than Tirapazamine.The 6(7)-fluoro and 6(7)-chloro compounds, 6e and 6h, showed the greatest hypoxia selectivity.Four of the compounds, 6e, 6f, 6h and 6i, killed the inner cells of multicellular tumor spheroids in vitro.In vivo Balb/c mice tolerated a dose of these four compounds twice the size of that of Tirapazamine.This study demonstrates that quinoxaline 1,4-di-N-oxides could provide useful hypoxia-selective therapeutic agents.
- Monge, Antonio,Palop, Juan A.,Cerain, Adela Lopez de,Senador, Virginia,Martinez-Crespo, Francisko J.,et al.
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p. 1786 - 1792
(2007/10/02)
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- Pigment compositions for solvent and water-based ink systems and the methods for producing them
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This invention is an azo pigment composition containing a water insoluble metal salt of a water soluble polymer; a method of preparing said composition and ink compositions prepared from said azo pigment compositions.
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- The reduction of benzofuroxans by ferrous salts and by thiophenol
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Treatment of benzofuroxan derivatives with ferrous sulphate in DMSO/water solution affords in high yield o-nitroanilines. o-Nitroaniline was also obtained by reduction of benzofuroxan with thiophenol in presence of catalytic amount of Fe2+ or Fe3+ salts.
- Gasco,Medana,Gasco
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p. 2707 - 2712
(2007/10/02)
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- Azo pigment compositions and process for their preparation
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This invention is that of an azo pigment composition containing about 1 to 10 percent by weight of a nonionic alkyl polyglycoside dispersing agent. The polyglycosides useful in the invention have the general formulae: wherein: M is an oxygen, sulfur, nitrogen phosphorous or silicon atom; n is an integer from 8 to 18, preferably 8 to 11 and X represents the number average degree of polymerization having a numerical value from about 1 to about 2. These azo pigment compositions are prepared by conducting the azo pigment coupling reaction in the presence of said alkyl polyglycoside. The resulting pigment exhibit superior application properties in water based ink systems.
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- o-Nitroaniline Derivatives. Part 8. Synthesis of Some Unsymmetrical Dimethylquinoxalines: A Long-Standing Problem Resolved
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Reduction of N-acetonyl-4-methyl-2-nitro-N-p-tolylsulphonylaniline, using tin(II) chloride in hydrochloric acid, gives 2,7-dimethylquinoxaline (42percent) together with di-p-tolyl disulphide and toluene-p-thiol. 2,6- and 2,5-Dimethylquinoxalines are similarly obtained from the appropriately substituted nitroanilines; the 2,8-dimethyl isomer, however, is obtained impure and in very low yield.
- Blaikley, David C.W.,Currie, David W,Smith, David M.,Watson, Susan A.,McNab, Hamish
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p. 367 - 369
(2007/10/02)
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- Mesoionic Oxadiazolium-olates and Oxatriazolium-olates from Aryl Isocyanides and Nitroform
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Nitroform converted p-nitrophenyl isocyanide into the mesoionic 3-p-nitrophenyl-1,2,3-oxadiazolium-5-olate (2) and 3-p-nitrophenyl-1,2,3,4-oxatriazolium-5-olate (3), together with p-nitroaniline; it converted p-tolyl isocyanide into the mesoionic 3-(2-nitro-4-methylphenyl)-1,2,3,4-oxatriazolium-5-olate together with 2-nitro-4-methylaniline and p-methylaniline.
- Boyer, Joseph H.,Moran, T.,Pillai, T. P.
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p. 1388 - 1389
(2007/10/02)
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- Process for the production of 2-aryl-2H-benzotriazoles
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A process for the production of 2-aryl-2H-benzotriazoles comprises reducing and cyclizing the corresponding o-nitroazobenzenes with hydrogen at a temperature in the range of about 20° C. to about 100° C. and at a pressure in the range of about 15 psia (1 atmosphere) to about 1000 psia (66 atmospheres) in an alkaline medium at a pH over 10 in the presence of a nickel catalyst, preferably molybdenum-promoted Raney nickel. High yields of pure product are obtained directly with a concomitant reduction of undesired by-product and a reduction in effluent pollution problems.
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- Process for the production of 2-aryl-2H-benzotriazoles
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A process for the production of 2-aryl-2H-benzotriazoles comprises reducing and cyclizing the corresponding o-nitroazobenzenes with hydrogen at a temperature in the range of about 20° C. to about 100° C. and at a pressure in the range of about 15 psia (1 atmosphere) to about 1000 psia (66 atmospheres) in an organic solvent mixture containing an organic amine at a pH over 10 in the presence of noble metal hydrogenation catalyst, preferably palladium. High yields of pure product are obtained with a concomitant reduction of undesired by-products and a reduction in effluent pollution problems.
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- Process for the production of 2-aryl-2H-benzotriazoles
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A process for the production of 2-aryl-2H-benzotriazoles comprises reducing and cyclizing the corresponding o-nitroazobenzenes with carbon monoxide at a temperature in the range of about 20° C. to about 150° C. and at a pressure in the range of about 15 psia (1 atmosphere) to about 1000 psia (66 atmospheres) in an alkaline medium at a pH over 10 in the presence of a copper-amine complex catalyst. High yields of pure product are obtained with a concomitant reduction of undesired by-products and a reduction in effluent pollution problems.
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- Process for the production of 2-aryl-2H-benzotriazoles
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An improved process for the production of 2-aryl-2H-benzotriazoles by the reduction of o-nitroazobenzene intermediates with zinc in alkaline medium comprises employing a ratio of moles of alkali to moles of o-nitroazobenzene intermediate in the range of 0.2-1.7/1 in the presence of less than 150 ppm of iron based on zinc used. The improved process results in higher yields of high purity products with a concomitant reduction in the amount of undesired cleavage amine by-products and a reduction in effluent pollution problems. The process is carried out in a polar/non-polar solvent mixture.
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- Azo pigments derived from 2-hydroxy-3-carboxynaphthalene containing a substituted or unsubstituted phthalimide
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Azo pigments derived from 2-hydroxy-3-carboxy-naphthalene and containing a substituted or unsubstituted phthalimide radical. The majority give red colorations and due to their excellent fastness properties are particularly valuable for use in surface coatings and resins.
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