890005-22-8

Basic information

• Product Name: 4,5,6,7-TETRAHYDRO-3-(TRIFLUOROMETHYL)-1H-INDAZOLE
• Synonyms: 4,5,6,7-TETRAHYDRO-3-(TRIFLUOROMETHYL)-1H-INDAZOLE;AKOS BBS-00002818;3-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOLE;3-TrifluoroMethyl-4,5,6,7-tetrahydroindazole;4,5,6,7-Tetrahydro-3-(trifluoroMethyl)-indazole;4,5,6,7-Tetrahydro-3-(trifluoromethyl)-2H-indazole;3-TrifluoroMethyl-4,5,6,7-tetrahydro-2H-indazole
• CAS NO: 890005-22-8
• Molecular Formula: C₈H₉F₃N₂
• Molecular Weight: 190.17
• Mol File: 890005-22-8.mol

Chemical Properties

• Melting Point: 121°C
• Boiling Point: 255.6±35.0℃ (760 Torr)
• Flash Point: 108.4±25.9℃
• Appearance: /
• Density: 1.345±0.06 g/cm3 (20 ºC 760 Torr)
• CAS DataBase Reference: 4,5,6,7-TETRAHYDRO-3-(TRIFLUOROMETHYL)-1H-INDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5,6,7-TETRAHYDRO-3-(TRIFLUOROMETHYL)-1H-INDAZOLE(890005-22-8)
• EPA Substance Registry System: 4,5,6,7-TETRAHYDRO-3-(TRIFLUOROMETHYL)-1H-INDAZOLE(890005-22-8)

Safety Data

• Hazardous Substances Data: 890005-22-8(Hazardous Substances Data)

Upstream product

• 6425-41-8 N-cyclohexylmorpholine 
• 407-25-0 trifluoroacetic anhydride 
• 108-94-1 cyclohexanone 
• 658-78-6 1-nitro-4-trifluoroacetoxy-benzene 
• 387-89-3 2-(2,2,2-trifluoroacetyl)cyclohexanone 
• 56734-75-9 2-pentafluoroethyl-cyclohexanone 

Downstream Products

• 950785-30-5 {4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]-phenyl}acetonitrile 
• 950785-31-6 1-[(4-nitrophenyl)methyl]-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole 
• 950785-45-2 1-(4-bromophenyl)-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole 
• 950785-44-1 1-(4-iodophenyl)-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole 
• 57631-05-7 3-(trifluoromethyl)-1H-indazole 
• 1057662-37-9 2-fluoro-4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]benzonitrile 
• 1057662-49-3 1-[2-fluoro-4-(1-pyrrolidinylcarbonyl)phenyl]-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole 
• 1057662-54-0 1-{3-fluoro-4-[2-oxo-2-(1-pyrrolidinyl)ethyl]phenyl}-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole 
• 1057662-63-1 1-{4-[(1,1-dioxido-2-isothiazolidinyl)methyl]-3-fluorophenyl}-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole 
• 1057662-68-6 1-[3-fluoro-4-(4-morpholinylcarbonyl)phenyl]-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole 

Relevant articles and documents

Pyrazole-3/5-carboxylic acids from 3/5-trifluoromethyl NH-pyrazoles

We report here the transformation of 3/5-trifluoromethylpyrazoles derivative into the corresponding NH-pyrazole-3/5-carboxylic acids. Moreover, from 4- or 5-iodinated-3/5-trifluoromethylpyrazoles building blocks and the use of Suzuki-Miyaura or Negishi reactions followed by the trifluoromethyl hydrolysis, we illustrate short and original accesses to many series of NH-pyrazole-3/5-carboxylic acids otherwise difficult to prepare.

Metal and boron derivatives of fluorinated cyclic 1,3-dicarbonyl compounds

Starting from the corresponding cyclic 1,3-diketones or other precursors (cyclic ketones as well as lactones), several new salts and chelate complexes of fluorinated 1,3-dicarbonyls were obtained. Their preparative significance was demonstrated by straigh

HETEROCYCLES USEFUL AS INHIBITORS OF CARBONIC ANHYDRASE

Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.

The structure of fluorinated indazoles: The effect of the replacement of a H by a F atom on the supramolecular structure of NH-indazoles

The structures of three NH-indazoles (3-methyl, 3-trifluoromethyl and 3-trifluoromethyl-4,5,6,7-tetrafluoroindazoles) have been determined by X-ray crystallography. These three compounds, together with 3-methyl-4,5,6,7- tetrafluoroindazole, whose X-ray st

Novel polyfluoroalkylated pyrazoles from 2-polyfluoroacylcycloalkanones and hydrazines: Syntheses and unequivocal molecular structure assignment

The reaction between 2-trifluoroacetylcycloalkanones and methylhydrazine or phenylhydrazine exclusively yields 3-CF3-pyrazoles. When the chain length of the polyfluorinated substituent in RFC(O) group increases, 5-RF-pyraz

Convenient and versatile synthesis of 3-(polyfluoroalkyl)pyrazoles

3-(Polyfluoroalkyl)pyrazoles 4 have been synthesized in excellent yields in a two-step sequence from polyfluoroalkyl iodides 1.The synthesis consisted of the reaction of iodides 1 with enamines or enol ethers to give α-polyfluoroalkyl carbonyl derivatives 3 followed by treatment with hydrazine monohydrate.A practical one-pot synthesis of pyrazoles 4 from iodides 1 gas also been developed and the reaction mechanism is discussed.