The phosphoramidate ProTide approach greatly enhances the activity of β-2′-C-methylguanosine against hepatitis C virus
β-2′-C-Methyl purines (1, 2) are known inhibitors of hepatitis C virus (HCV). We herein report the synthesis, biological and enzymatic evaluation of their 5′-phosphoramidate ProTides. Described herein are seven l-alanine phosphoramidate derivatives with v
McGuigan, Christopher,Perrone, Plinio,Madela, Karolina,Neyts, Johan
scheme or table
p. 4316 - 4320
(2010/06/19)
Efficient synthesis of 2′-C-β-methylguanosine
2′-β-Methyl nucleosides have potential value as therapeutic agents and as nucleoside analogues for exploring RNA biology. Here we develop a strategy for efficient synthesis for 2′-C-β-methylguanosine (3). Starting from 1,2,3,5-tetra-O-benzoyl-2-C-β-methyl
Li, Nan-Sheng,Piccirilli, Joseoh A.
p. 4018 - 4020
(2007/10/03)
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