890131-90-5

Usage

Uses

Used in Pharmaceutical Industry:
N-Acetyl-2'-C-methyl-guanosine 2',3',5'-tribenzoate is used as a potential antiviral agent for its pharmacological properties. Its tribenzoate ester modification may improve its bioavailability and stability, making it a valuable compound for further research and development in the field of medicinal chemistry.

Upstream product

• 19962-37-9 N-(6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide 
• 1146951-95-2 5-O-benzyl-1,2,3-tri-O-benzoyl-2-C-methyl-α,β-D-ribofuranose 

Downstream Products

• 374750-30-8 2'-C-methylguanosine 

Relevant academic research and scientific papers

The phosphoramidate ProTide approach greatly enhances the activity of β-2′-C-methylguanosine against hepatitis C virus

β-2′-C-Methyl purines (1, 2) are known inhibitors of hepatitis C virus (HCV). We herein report the synthesis, biological and enzymatic evaluation of their 5′-phosphoramidate ProTides. Described herein are seven l-alanine phosphoramidate derivatives with v

Efficient synthesis of 2′-C-β-methylguanosine

2′-β-Methyl nucleosides have potential value as therapeutic agents and as nucleoside analogues for exploring RNA biology. Here we develop a strategy for efficient synthesis for 2′-C-β-methylguanosine (3). Starting from 1,2,3,5-tetra-O-benzoyl-2-C-β-methyl