89277-99-6

Basic information

• Product Name: (2-CHLORO-4-NITROPHENYL)-ACETONITRILE
• Synonyms: 2-(2-CHLORO-4-NITROPHENYL)ACETONITRILE;(2-CHLORO-4-NITROPHENYL)-ACETONITRILE
• CAS NO: 89277-99-6
• Molecular Formula: C₈H₅ClN₂O₂
• Molecular Weight: 196.59
• Mol File: 89277-99-6.mol

Chemical Properties

• Boiling Point: 352.4°C at 760 mmHg
• Flash Point: 166.9°C
• Appearance: /
• Density: 1.409g/cm³
• Vapor Pressure: 3.85E-05mmHg at 25°C
• Refractive Index: 1.591
• CAS DataBase Reference: (2-CHLORO-4-NITROPHENYL)-ACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: (2-CHLORO-4-NITROPHENYL)-ACETONITRILE(89277-99-6)
• EPA Substance Registry System: (2-CHLORO-4-NITROPHENYL)-ACETONITRILE(89277-99-6)

Safety Data

• Hazardous Substances Data: 89277-99-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(2-Chloro-4-nitrophenyl)-acetonitrile is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, (2-Chloro-4-nitrophenyl)-acetonitrile is utilized as an intermediate in the production of agrochemicals. Its role in the synthesis of these chemicals aids in the development of effective solutions for agricultural applications, such as pest control and crop protection.
Used in Fine Chemicals Production:
(2-Chloro-4-nitrophenyl)-acetonitrile is also employed as a building block in the creation of fine chemicals. Its versatility and reactivity make it a valuable component in the synthesis of specialty chemicals used in various industries, including fragrances, dyes, and other high-value products.
Safety Precautions:
It is crucial to handle (2-Chloro-4-nitrophenyl)-acetonitrile with care, as it may pose health risks if swallowed, inhaled, or comes into contact with the skin. Proper safety measures, such as wearing protective gear and working in a well-ventilated area, should be taken to minimize potential hazards associated with this compound.

InChI:InChI=1/C8H5ClN2O2/c9-8-5-7(11(12)13)2-1-6(8)3-4-10/h1-2,5H,3H2

Upstream product

• 121-73-3 3-Nitrochlorobenzene 
• 5219-61-4 (phenylthio)acetonitrile 
• 107-14-2 chloroacetonitrile 
• 350-30-1 3-chloro-4-fluoronitrobenzene 
• 105-56-6 ethyl 2-cyanoacetate 
• 121-86-8 2-chloro-4-nitrotoluene 

Downstream Products

• 952202-57-2 C₂₁H₁₇Cl₂N₅O₄S 
• 952202-56-1 N-[4-(7-amino-3-hydroxymethyl-pyrazolo[1,5-a]pyrimidin-6-yl)-3-chlorophenyl]-2-chlorobenzenesulfonamide 
• 952202-55-0 N-[4-(7-amino-3-chloromethyl-pyrazolo[1,5-a]pyrimidin-6-yl)-3-chlorophenyl]-2-chlorobenzenesulfonamide 
• 952202-58-3 (Z)-2-chloro-N-[3-chloro-4-(1-cyano-2-dimethylaminovinyl)phenyl]-benzenesulfonamide 
• 180150-18-9 (4-amino-2-chloro-phenyl)-acetonitrile 
• 609347-35-5 2-(2-chloro-4-nitro-benzyl)-1-methyl-1H-imidazole 
• 609347-34-4 2-(2-chloro-4-nitro-benzyl)-1H-imidazole 
• 609347-36-6 3-chloro-4-(1-methyl-1H-imidazol-2-ylmethyl)-phenylamine 
• 848133-57-3 6-amino-4-[3-chloro-4-(4-phenyl-thiazol-2-ylmethyl)-phenylamino]-7-methoxy-quinoline-3-carbonitrile 
• 952202-60-7 (Z)-2-(2-chloro-4-nitro-phenyl)-3-dimethylaminoacrylonitrile 
• 848133-05-1 2-(4-amino-2-chlorophenyl)ethanethioamide 

Relevant articles and documents

NOVEL BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE

The present invention provides new compounds of formula I, wherein Q, R1, R2, R4, R5, R6, Xi, R7, R8, M and G1 nare defined as in formula I; invention compounds are modulators of follicle-stimulating hormone - ("FSH") which are useful for male and female contraception as well as other disorders modulated by FSH receptor.

1H-IMIDAZO[4,5-C]QUINOLINE DERIVATIVES IN THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES

The invention relates to the use of imidazoquinolines and salts thereof in the treatment of protein kinase diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, imidazoquinolines for use in the treatment of protein kinase dependent diseases, a method of treatment against said diseases, comprising administering the imidazoquinolines to a warm-blooded animal, especially a human, pharmaceutical preparations comprising an imidazoquinoline, especially for the treatment of a protein kinase dependent disease, novel imidazoquinolines, and a process for the preparation of the novel imidazoquinolines.

Vicarious Nucleophilic Substitution of Hydrogen in Nitroarenes with α-Substituted Nitriles and Esters. Direct α-Cyanoalkylation and α-Carbalkoxyalkylation of Nitroarenes

Carbanions generated from alkanenitriles bearing α-chloro, α-OR, or α-SR groups and from aliphatic esters bearing α-SR groups react with mononitroarenes to replace hydrogen atoms of the nitroaromatic ring ortho or para to the nitro group with α-cyanoalkyl or α-carbalkoxyalkyl substituents.The nucleophilic replacement of hydrogen with such carbanions proceeds faster than substitution of halogen ortho or para to the nitro group.