89284-20-8

Basic information

• Product Name: 3-CHLORO-4-HYDROXYPYRIDINE
• Synonyms: 3-CHORO-4-HYDROXYPYRIDINE;3-Chloropyridin-4-ol;3-chloro-4-Pyridinol;3-chloro-1H-pyridin-4-one;3-CHLORO-4-HYDROXYPYRIDINE;4-Hydroxy-3-Chloropyridine;3-Chloro-4-hydroxypyridine97%;4-Pyridinol,3-chloro-(7CI,9CI)
• CAS NO: 89284-20-8
• Molecular Formula: C₅H₄ClNO
• Molecular Weight: 129.54
• Product Categories: Pyridines;Heterocycle-Pyridine series;PYRIDINE
• Mol File: 89284-20-8.mol

Chemical Properties

• Melting Point: 204-205℃
• Boiling Point: 224.8 °C at 760 mmHg
• Flash Point: 89.8 °C
• Appearance: /
• Density: 1.35 g/cm³
• Vapor Pressure: 0.0894mmHg at 25°C
• Refractive Index: 1.569
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.77±0.18(Predicted)
• CAS DataBase Reference: 3-CHLORO-4-HYDROXYPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-4-HYDROXYPYRIDINE(89284-20-8)
• EPA Substance Registry System: 3-CHLORO-4-HYDROXYPYRIDINE(89284-20-8)

Safety Data

• Hazardous Substances Data: 89284-20-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-CHLORO-4-HYDROXYPYRIDINE is used as a chemical intermediate for the synthesis of pharmaceutical drugs. Its unique structure allows for the development of new drug candidates with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 3-CHLORO-4-HYDROXYPYRIDINE is used as a building block for the production of fungicides and herbicides. Its incorporation into these products contributes to their effectiveness in controlling pests and diseases in agriculture.
As a potentially hazardous chemical, 3-CHLORO-4-HYDROXYPYRIDINE requires careful handling and adherence to proper safety protocols to minimize risks during its use in various applications.

InChI:InChI=1/C5H4ClNO/c6-4-3-7-2-1-5(4)8/h1-3H,(H,7,8)

Upstream product

• 626-64-2 pyridin-4-ol 

Downstream Products

• 1357589-10-6 3-chloro-1-[3-(trifluoromethyl)phenyl]pyridin-4(1H)-one 
• 1357589-07-1 3-(1-phenyl-1H-pyrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]pyridin-4(1H)-one 
• 89379-79-3 3-Chlor-4-methoxy-pyridin 

Relevant articles and documents

Preparation method of pyridine derivative (by machine translation)

To the method, piperidine-4-one hydrochloride is used as a raw material, and a series of pyridine derivatives are obtained through halogenation reaction and elimination reaction. The reaction is eliminated by reacting piperidine-4-one hydrochloride with a specific amount of the 3,5 - halogenating agent in a halogenation 3, 3, 5 - reaction with a halogen-3, 3, 5, 5 - based reaction, followed by reaction with a pyridine derivative of a hydroxyl group, an amino group 4 - or a dimethylamino group, respectively, by eliminating the reaction with a different kind of basic agent. The method is simple and convenient to operate, mild in condition, short in technological process, low in waste water yield, environment-friendly, low in cost and beneficial to green industrial production of the pyridine derivative. (by machine translation)

Convenient chlorination of some special aromatic compounds using N-chlorosuccinimide

Some chlorinated aromatic compounds, including indole, benzofuran, carbazole, pyridine and aniline derivatives, are difficult to obtain through convenient chlorination. We herein report their efficient synthesis through chlorination with N-chlorosuccinimide (NCS). Optimization of the reaction conditions, including the temperature and the choice of solvent, was also investigated. This approach, which is characterized by a facile procedure, comparatively high yields and environmentally friendly features, provides a straightforward and inexpensive route to several chlorinated aromatic compounds. Georg Thieme Verlag Stuttgart · New York.