- QUINAZOLINE DERIVATIVES AS TAM FAMILY KINASE INHIBITORS
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Disclosed are compounds, compositions and methods for treating diseases, syndromes, conditions and disorders that are affected by the modulation of the activity of, e.g., the inhibition of, one or more members of the TAM family kinases.
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Paragraph 0154; 0162
(2015/06/08)
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- A simplified process for the manufacture of AZD0530, a potent SRC kinase inhibitor
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An efficient process for the manufacture of AZD0530 1, a potent SRC kinase inhibitor, has been developed. The key transformation, reaction of monofluoroanilide 7 with alcohol 8, was much simplified between manufacturing campaigns. The development of a robust, efficient, and scalable process for this transformation drew on both a practical and theoretical understanding of the process and is described herein
- Raw, Steven A.,Taylor, Brian A.,Tomasi, Simone
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p. 688 - 692
(2011/12/01)
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- CHEMICAL PROCESS
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The present invention relates to chemical processes useful in the manufacture of the compound 4-(6-chloro-2,3-methylenedioxyanilino)-7-[2-(4-methylpiperazin-1-yl)ethoxy]- 5-tetrahydropyran-4-yloxyquinazoline (the active entity within AZD0530), to intermed
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Page/Page column 54
(2008/06/13)
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