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3-FLUORO-4'-METHOXY[1,1'-BIPHENYL]-4-AMINE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

893734-49-1

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893734-49-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 893734-49-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,3,7,3 and 4 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 893734-49:
(8*8)+(7*9)+(6*3)+(5*7)+(4*3)+(3*4)+(2*4)+(1*9)=221
221 % 10 = 1
So 893734-49-1 is a valid CAS Registry Number.

893734-49-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-Fluoro-4'-methoxy[1,1'-biphenyl]-4-amine

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:893734-49-1 SDS

893734-49-1Downstream Products

893734-49-1Relevant articles and documents

Discovery of a novel series of DHODH inhibitors by a docking procedure and QSAR refinement

Leban, Johann,Saeb, Wael,Garcia, Gabriel,Baumgartner, Roland,Kramer, Bernd

, p. 55 - 58 (2004)

A novel series of DHODH inhibitors was developed based on a lead which was obtained by a docking procedure and a medicinal chemistry exploration. The activity of the initial lead was improved by a QSAR method to yield low nanomolar inhibitors.

Structural optimization and structure–activity relationship of 4-thiazolidinone derivatives as novel inhibitors of human dihydroorotate dehydrogenase

Zeng, Fanxun,Quan, Lina,Yang, Guantian,Qi, Tiantian,Zhang, Letian,Li, Shiliang,Li, Honglin,Zhu, Lili,Xu, Xiaoyong

, (2019/08/07)

Human dihydroorotate dehydrogenase (hDHODH), one of the attractive targets for the development of immunosuppressive drugs, is also a potential target of anticancer drugs and anti-leukemic drugs. The development of promising hDHODH inhibitors is in high demand. Based on the unique binding mode of our previous reported 4-thiazolidinone derivatives, via molecular docking method, three new series 4-thiazolidinone derivatives were designed and synthesized as hDHODH inhibitors. The preliminary structure–activity relationship was investigated. Compound 9 of biphenyl series and compound 37 of amide series displayed IC50 values of 1.32 μM and 1.45 μM, respectively. This research will provide valuable reference for the research of new structures of hDHODH inhibitors.

Trimethoxybenzanilide-based P-glycoprotein modulators: An interesting case of lipophilicity tuning by intramolecular hydrogen bonding

Tardia, Piero,Stefanachi, Angela,Niso, Mauro,Stolfa, Diana Antonella,Mangiatordi, Giuseppe Felice,Alberga, Domenico,Nicolotti, Orazio,Lattanzi, Gianluca,Carotti, Angelo,Leonetti, Francesco,Perrone, Roberto,Berardi, Francesco,Azzariti, Amalia,Colabufo, Nicola Antonio,Cellamare, Saverio

, p. 6403 - 6418 (2014/10/16)

One of the principal reasons for the chemotherapy failure is the overexpression of drug efflux pumps, ABCB1 (also known as MDR1 or P-gp) and ABCC1 (also known as MRP1), whose inhibition remains a priority to circumvent drug resistance. We have recently sh

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