- INHIBITOR OF BTK AND MUTANTS THEREOF
-
The disclosure includes compounds of Formula (I) (1) wherein Q0, Q1, Q2, Q3, Q4, Z, W, i, j, m, n, Warhead, R0, R1, R3, R4, R5, R6, and R7, are defined herein. Also disclosed is a method for treating a neoplastic disease, autoimmune disease, and inflammatory disorder with these compounds.
- -
-
Page/Page column 128-129; 136
(2020/09/12)
-
- N-SUBSTITUTED TETRAHYDROTHIENOPYRIDINE DERIVATIVES AND USES THEREOF
-
A compound of Formula (I) is provided that has been shown to be useful for treating a disease caused by a viral infection: (I) wherein R1, R2, R3, A, L, m, n, p and q are as defined herein.
- -
-
Paragraph 00234
(2020/01/11)
-
- PYRAZOLO PYRIMIDINE DERIVATIVES
-
The present invention relates to pyrazolo pyrimidine derivatives, to methods of preparing these, to combinations and pharmaceutical composition comprising these, and to their use in the treatment of diseases and disorders which may for example involve autoimmune diseases, angiogenesis, pain, and/or inflammatory diseases.
- -
-
Paragraph 0338-0339
(2013/03/26)
-
- Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase
-
A series of substituted 4,5,6,7-tetrahydrothieno[3,2-c]pyridines (THTPs) was synthesized and evaluated for their human phenylethanolamine N-methyltransferase (hPNMT) inhibitory potency and affinity for the α2-adrenoceptor. The THTP nucleus was
- Grunewald, Gary L.,Seim, Mitchell R.,Bhat, Seema R.,Wilson, Marc E.,Criscione, Kevin R.
-
p. 542 - 559
(2008/09/16)
-
- (PIPERIDINYLOXY)PHENYL, (PIPERIDINYLOXY)PYRIDINYL, (PIPERIDINYLSULFANYL)PHENYL AND (PIPERIDINYLSULFANYL)PYRIDINYL COMPOUNDS AS 5-HT1F AGONISTS
-
The present invention relates to compounds of formula 1: and pharmaceutically acceptable acid addition sails thereof. The compounds of the present invention are useful for activating 5-HTIF receptors, inhibiting neuronal protein extravasation, and for the treatment or preverition of migraine in mammals, particularly humans.
- -
-
-
- FIRST ASYMMETRIC SYNTHESIS OF 4-PIPERIDONES. PREPARATION OF OPTICALLY ACTIVE DIASTEREOMERS OF 1-α-PHENYLETHYL-2-METHYL-4-PIPERIDONE
-
The fundamental possibility of carrying out the asymmetric synthesis of 4-piperidones on the basis of the transamination of 1-substituted 2-methyl-4-piperidone methiodides by optically active α-phenylethylamine was demonstrated; the optical yield of the asymmetric transamination is 50percent.The occurrence of asymmetric synthesis was confirmed by the isolation of enantiomers of 2-methyl-4-piperidol by reduction of the individual diastereomers of 1-α-phenyl-ethyl-2-methyl-4-piperidone to the corresponding 4-piperidols with subsequent removal of the chiral substituent attached to the nitrogen atom.
- Grishina, G. V.,Potapov, V. M.,Gudasheva, T. A.,Abdulganeeva, S. A.
-
p. 1132 - 1136
(2007/10/02)
-