89467-36-7

Usage

Uses

Used in Pharmaceutical Industry:
(S)-2-Methyl-1-((S)-1-phenylethyl) piperidin-4-one is used as a chiral building block for the synthesis of various pharmaceuticals and biologically active compounds. Its unique structure and stereochemistry make it a valuable component in the development of new drugs with improved efficacy and selectivity.
Used in Organic Chemistry Research:
In the field of organic chemistry, (S)-2-Methyl-1-((S)-1-phenylethyl) piperidin-4-one is utilized as a key intermediate for the synthesis of complex organic molecules. Its versatile reactivity and structural features enable the creation of a wide range of chemical entities with potential applications in various industries.
Used in Drug Development:
(S)-2-Methyl-1-((S)-1-phenylethyl) piperidin-4-one exhibits potential pharmacological and therapeutic properties, making it a valuable compound for research and drug development. Its exploration in the treatment of various medical conditions, including neurological and psychiatric disorders, highlights its significance in the discovery of novel therapeutic agents.
Used in Medicinal Chemistry:
In medicinal chemistry, (S)-2-Methyl-1-((S)-1-phenylethyl) piperidin-4-one is employed as a structural motif for the design and optimization of new drug candidates. Its incorporation into molecular frameworks can lead to the development of compounds with enhanced pharmacological profiles and improved therapeutic potential.
Overall, (S)-2-Methyl-1-((S)-1-phenylethyl) piperidin-4-one is a versatile and promising compound with applications spanning across various fields, including pharmaceuticals, organic chemistry, drug development, and medicinal chemistry. Its unique properties and potential make it an invaluable asset in the pursuit of innovative and effective therapeutic solutions.

Upstream product

• 2627-86-3 (-)-α-methylbenzylamine 
• 103539-59-9 1-butyl-2-methyl-4-piperidone methiodide 
• 13604-71-2 1-butyl-2-methyl-4-piperidone 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 27806-90-2 1,2-dimethyl-4-piperidone iodomethylate 
• 35172-85-1 1,4-hexadien-3-one 
• 1826-67-1 vinyl magnesium bromide 
• 109480-79-7 (E)-N-methoxy-N-methyl-2-butenamide 
• 10575-36-7 (1E,4E)-hexa-1,4-dien-3-one 

Downstream Products

• 89451-57-0 (-)-cis-1-(S-α-phenylethyl)-2-methyl-4-piperidol 
• 89451-58-1 (+)-cis-2-methyl-4-piperidol 
• 89451-56-9 (+)-cis-1-(S-α-phenylethyl)-2-methyl-4-piperidol 
• 790667-49-1 (S)-2-methyl-4-oxopiperidine-1-carboxylic acid tert-butyl ester 
• 89467-37-8 (R)-2-methyl-1-((S)-1-phenylethyl)piperidin-4-one 

Relevant academic research and scientific papers

INHIBITOR OF BTK AND MUTANTS THEREOF

The disclosure includes compounds of Formula (I) (1) wherein Q0, Q1, Q2, Q3, Q4, Z, W, i, j, m, n, Warhead, R0, R1, R3, R4, R5, R6, and R7, are defined herein. Also disclosed is a method for treating a neoplastic disease, autoimmune disease, and inflammatory disorder with these compounds.

N-SUBSTITUTED TETRAHYDROTHIENOPYRIDINE DERIVATIVES AND USES THEREOF

A compound of Formula (I) is provided that has been shown to be useful for treating a disease caused by a viral infection: (I) wherein R1, R2, R3, A, L, m, n, p and q are as defined herein.

PYRAZOLO PYRIMIDINE DERIVATIVES

The present invention relates to pyrazolo pyrimidine derivatives, to methods of preparing these, to combinations and pharmaceutical composition comprising these, and to their use in the treatment of diseases and disorders which may for example involve autoimmune diseases, angiogenesis, pain, and/or inflammatory diseases.

Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase

A series of substituted 4,5,6,7-tetrahydrothieno[3,2-c]pyridines (THTPs) was synthesized and evaluated for their human phenylethanolamine N-methyltransferase (hPNMT) inhibitory potency and affinity for the α2-adrenoceptor. The THTP nucleus was

(PIPERIDINYLOXY)PHENYL, (PIPERIDINYLOXY)PYRIDINYL, (PIPERIDINYLSULFANYL)PHENYL AND (PIPERIDINYLSULFANYL)PYRIDINYL COMPOUNDS AS 5-HT1F AGONISTS

The present invention relates to compounds of formula 1: and pharmaceutically acceptable acid addition sails thereof. The compounds of the present invention are useful for activating 5-HTIF receptors, inhibiting neuronal protein extravasation, and for the treatment or preverition of migraine in mammals, particularly humans.

FIRST ASYMMETRIC SYNTHESIS OF 4-PIPERIDONES. PREPARATION OF OPTICALLY ACTIVE DIASTEREOMERS OF 1-α-PHENYLETHYL-2-METHYL-4-PIPERIDONE

The fundamental possibility of carrying out the asymmetric synthesis of 4-piperidones on the basis of the transamination of 1-substituted 2-methyl-4-piperidone methiodides by optically active α-phenylethylamine was demonstrated; the optical yield of the asymmetric transamination is 50percent.The occurrence of asymmetric synthesis was confirmed by the isolation of enantiomers of 2-methyl-4-piperidol by reduction of the individual diastereomers of 1-α-phenyl-ethyl-2-methyl-4-piperidone to the corresponding 4-piperidols with subsequent removal of the chiral substituent attached to the nitrogen atom.