Inhibition of rho kinase (ROCK) has been recognized as an important target for a number of diseases, including glaucoma. Herein we report SAR development around two hits from a kinase library that led to the discovery of the ROCK inhibitor compound 38. In vitro and in vivo analysis of this compound, including its effects in a monkey model of glaucoma will be discussed.
Henderson, Alan J.,Hadden, Mark,Guo, Cheng,Douglas, Neema,Decornez, Helene,Hellberg, Mark R.,Rusinko, Andrew,McLaughlin, Marsha,Sharif, Naj,Drace, Colene,Patil, Raj
scheme or table
p. 1137 - 1140
(2010/06/15)
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