89501-90-6

Basic information

• Product Name: 1-METHYL-1H-PYRAZOLE-3-SULFONYL CHLORIDE
• Synonyms: 1-METHYL-1H-PYRAZOLE-3-SULFONYL CHLORIDE;1H-Pyrazole-3-sulfonyl chloride, 1-methyl-
• CAS NO: 89501-90-6
• Molecular Formula: C₄H₅ClN₂O₂S
• Molecular Weight: 180.6127
• Mol File: 89501-90-6.mol

Chemical Properties

• Boiling Point: 295.672 °C at 760 mmHg
• Flash Point: 132.618 °C
• Appearance: /
• Density: 1.605 g/cm³
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.622
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -3.70±0.10(Predicted)
• CAS DataBase Reference: 1-METHYL-1H-PYRAZOLE-3-SULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-1H-PYRAZOLE-3-SULFONYL CHLORIDE(89501-90-6)
• EPA Substance Registry System: 1-METHYL-1H-PYRAZOLE-3-SULFONYL CHLORIDE(89501-90-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• RIDADR: UN1759
• Hazardous Substances Data: 89501-90-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Methyl-1H-pyrazole-3-sulfonyl Chloride is used as a synthetic reagent for the preparation of glucokinase activators. These activators are potent in enzyme and cell assays, playing a crucial role in the development of novel therapeutic agents for the treatment of diabetes and related metabolic disorders.
In the synthesis process, 1-Methyl-1H-pyrazole-3-sulfonyl Chloride serves as a key intermediate, enabling the formation of various glucokinase activators with potential applications in the management of glucose homeostasis and improving insulin sensitivity. This makes it a valuable component in the discovery and advancement of new drugs targeting diabetes and its complications.

InChI:InChI=1/C4H5ClN2O2S/c1-7-3-2-4(6-7)10(5,8)9/h2-3H,1H3

Upstream product

• 1904-31-0 methyl-1 amino-3 pyrazole 

Downstream Products

• 1383480-65-6 N-{3-[7-(1-{3-(Cyanomethyl)-1-[(1-methyl-1H-pyrazol-3-yl)sulfonyl]azetidin-3-yl}-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]phenyl}-N'-(2,2,2-trifluoroethyl)urea 
• 1257583-32-6 6-[benzyl-(1-methyl-1H-pyrazole-3-sulfonyl)-amino]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 1256961-28-0 1-methyl-1H-pyrazole-3-sulfonic acid benzyl-(1-oxo-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide 
• 1256961-01-9 1-methyl-1H-pyrazole-3-sulfonic acid (4-chloro-benzyl)-(1-oxo-1,2,3,4-tetrahydro-isoquinolin-7-yl)-amide 
• 1213702-33-0 1-methyl-1H-pyrazole-3-sulfonic acid (4-chloro-benzyl)-(3-hydroxy-phenyl)-amide 
• 1214251-52-1 3-[(4-chloro-benzyl)-(1-methyl-1H-pyrazole-3-sulfonyl)-amino]-benzoic acid tert-butyl ester 
• 88398-97-4 1-methyl-1H-pyrazole-3-sulfonamide 

Relevant articles and documents

NLRP3 INHIBITORS

The present application relates to compounds with NLRP3inhibitory activity and to associated salts, solvates, prodrugs and pharmaceutical compositions. The present application further relates to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by NLRP3inhibition.

SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME

ABSTRACT The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in the treatment of a wide range of disorders in which the inflammation process, or more specifically the NLRP3 inflammasome, have been implicated as being a key factor.

Herbicidal diazoles sulfonamides

This invention relates to herbicidal heterocyclic aminocarbonyl diazole sulfonamides compounds, compositions thereof and a method for their use to control the growth of undesired vegetation.