89544-84-3

Basic information

• Product Name: Cyclopropanecarboxylic acid, 1-broMo-
• Synonyms: Cyclopropanecarboxylic acid, 1-broMo-;1-bromocyclopropane-1-carboxylic acid
• CAS NO: 89544-84-3
• Molecular Formula: C4H5BrO2
• Molecular Weight: 164.9853
• Mol File: 89544-84-3.mol

Chemical Properties

• Melting Point: 78℃
• Boiling Point: 235.1±23.0 °C(Predicted)
• Appearance: /
• Density: 2.107±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 2.84±0.20(Predicted)
• CAS DataBase Reference: Cyclopropanecarboxylic acid, 1-broMo-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropanecarboxylic acid, 1-broMo-(89544-84-3)
• EPA Substance Registry System: Cyclopropanecarboxylic acid, 1-broMo-(89544-84-3)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38
• Safety Statements: 26-37
• TSCA: No
• Hazardous Substances Data: 89544-84-3(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
Cyclopropanecarboxylic acid, 1-bromo-, is utilized as a key intermediate in the synthesis of various organic compounds. Its unique cyclopropane ring and bromine atom contribute to its reactivity, allowing for the formation of diverse chemical structures.
Used in Pharmaceutical Research:
Cyclopropanecarboxylic acid, 1-bromoserves as a valuable building block in the development of new pharmaceuticals. Its unique structure and reactivity enable the creation of novel drug candidates with potential therapeutic applications.
Used in Drug Discovery:
Cyclopropanecarboxylic acid, 1-bromo-, is employed in drug discovery processes to explore its potential as a precursor for the development of new drugs. Its unique chemical properties may contribute to the discovery of innovative therapeutic agents.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, Cyclopropanecarboxylic acid, 1-bromo- is used to manipulate chemical structures and design new molecules with specific biological activities. Its cyclopropane ring and bromine atom provide opportunities for the creation of novel chemical entities with potential therapeutic benefits.

Upstream product

• 89544-83-2 Ethyl 1-bromocyclopropanecarboxylate 
• 96999-01-8 1-(1-bromocyclopropyl)formic acid methyl ester 

Relevant articles and documents

Synthesis method of 5-fluoro-2-(1-bromocyclopropyl) pyridine

The invention relates to a synthesis method of 5-fluoro-2-(1-bromocyclopropyl) pyridine. 1,4-butyrolactone, ethyl 4-bromobutyrate and 5-fluoro-2-mercaptopyridine are used as raw materials to prepare 5-fluoro-2-(1-bromocyclopropyl) pyridine through eleven steps of reaction. A synthetic route of the 5-fluoro-2-(1-bromocyclopropyl) pyridine is as follows: (as described in the specification). The invention has the advantages that the synthesis method of 5-fluoro-2-(1-bromocyclopropyl) pyridine improves the yield and provides an efficient synthesis method for the synthesis of the compound.

Trispirododecane-4,8,12-trione and Other Oligomers of Carbonylcyclopropane. The Organozinc Route

1-Bromocyclopropanecarboxylic acid (8) and its chloride (9) were prepared from γ-butyrolactone on a 20-100-g scale.Dehalogenation of 9 with zinc-copper couple in acetonitrile gave not only the known dispiro octane-4,8-dione (3) but also the aesthetically pleasing title compound 10 and 6-cyclopropylidene-5-oxaspirohexan-4-one (11) as well as tetracyclic α-alkylidene-γ-butyrolactone 12, i.e., 3-(oxodispirooctan-4-ylidene)tetrahydro-2-furanone. "Zinc carbon enolate" 13a is considered to be an important intermediate en route to 10 in solventacetonitrile.The X-ray crystal structure of 10 shows the molecule to be nearly planar with very short distal cyclopropane carbon-carbon bonds .