96999-01-8

Usage

Uses

Used in Pharmaceutical Synthesis:
Methyll-bromo-cyclopropanecarboxylate is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the formation of complex molecular structures. Its reactivity allows for the development of new drugs with specific therapeutic properties.
Used in Agrochemical Production:
In the agrochemical industry, Methyll-bromo-cyclopropanecarboxylate is utilized as a precursor in the production of pesticides and other crop protection agents, enhancing the effectiveness of these products in managing agricultural pests and diseases.
Used in Organic Synthesis:
Methyll-bromo-cyclopropanecarboxylate is used as a versatile reagent in organic synthesis for its capacity to undergo multiple chemical reactions, facilitating the creation of a wide array of organic compounds for various applications.
Used in Research and Development:
In research settings, Methyll-bromo-cyclopropanecarboxylate serves as an important tool for exploring new chemical pathways and mechanisms, contributing to the advancement of chemical knowledge and the discovery of novel applications.

InChI:InChI=1S/C5H7BrO2/c1-8-4(7)5(6)2-3-5/h2-3H2,1H3

Upstream product

• 29547-04-4 methyl 2,4-dibromobutanoate 
• 24666-02-2 methyl 2-bromo-4-chlorobutyrate 

Downstream Products

• 1363382-27-7 methyl 1-(pyrazin-2-yl)cyclopropanecarboxylate 
• 824937-45-3 methyl 1-(4-aminophenyl)cyclopropanecarboxylate 
• 943118-81-8 methyl 1-(3-chlorophenyl)cyclopropanecarboxylate 
• 1185886-64-9 methyl 1-(2-methoxy-6-methylphenyl)cyclopropanecarboxylate 
• 50915-29-2 (1-bromocyclopropyl)methanol 
• 89544-84-3 1-Bromocyclopropanecarboxylic acid 

Relevant academic research and scientific papers

Synthesis method of 5-fluoro-2-(1-bromocyclopropyl) pyridine

The invention relates to a synthesis method of 5-fluoro-2-(1-bromocyclopropyl) pyridine. 1,4-butyrolactone, ethyl 4-bromobutyrate and 5-fluoro-2-mercaptopyridine are used as raw materials to prepare 5-fluoro-2-(1-bromocyclopropyl) pyridine through eleven steps of reaction. A synthetic route of the 5-fluoro-2-(1-bromocyclopropyl) pyridine is as follows: (as described in the specification). The invention has the advantages that the synthesis method of 5-fluoro-2-(1-bromocyclopropyl) pyridine improves the yield and provides an efficient synthesis method for the synthesis of the compound.

Synthesis method of 1-(1-halogenated cyclopropyl) formic ether compound

The invention discloses a synthesis method of a 1-(1-halogenated cyclopropyl) formic ether compound. The 1-(1-halogenated cyclopropyl) formic ether compound is prepared by taking a 2,4-dihalogenated butyrate compound as a raw material and under the action of dihydric alcohol sodium. The method disclosed by the invention is rapid in reaction and high in yield, and solves the problem that the 1-(1-halogenated cyclopropyl) formic ether compound can not be simply and rapidly synthesized. The synthesis method is used for preparing the 1-(1-halogenated cyclopropyl) formic ether compound.

An efficient synthesis of 1-bromo-1-cyanocyclopropane

An efficient process for the synthesis of 1-bromo-1-cyanocyclopropane has been developed starting from inexpensive γ-butyrolactone via bromination, cyclisation, ammoniation and dehydration reaction. The sequence proceeds in good yield.

Trispirododecane-4,8,12-trione and Other Oligomers of Carbonylcyclopropane. The Organozinc Route

1-Bromocyclopropanecarboxylic acid (8) and its chloride (9) were prepared from γ-butyrolactone on a 20-100-g scale.Dehalogenation of 9 with zinc-copper couple in acetonitrile gave not only the known dispiro octane-4,8-dione (3) but also the aesthetically pleasing title compound 10 and 6-cyclopropylidene-5-oxaspirohexan-4-one (11) as well as tetracyclic α-alkylidene-γ-butyrolactone 12, i.e., 3-(oxodispirooctan-4-ylidene)tetrahydro-2-furanone. "Zinc carbon enolate" 13a is considered to be an important intermediate en route to 10 in solventacetonitrile.The X-ray crystal structure of 10 shows the molecule to be nearly planar with very short distal cyclopropane carbon-carbon bonds .