895929-56-3

Basic information

• Product Name: 1-(3,4-dichlorobenzyl)-1H-pyrazol-3-amine
• Synonyms: 1-(3,4-dichlorobenzyl)-1H-pyrazol-3-amine;1-[(3,4-dichlorophenyl)methyl]-1H-pyrazol-3-amine
• CAS NO: 895929-56-3
• Molecular Formula: C₁₀H₉Cl₂N₃
• Molecular Weight: 242.10456
• Mol File: 895929-56-3.mol

Chemical Properties

• Boiling Point: 427.2±40.0 °C(Predicted)
• Appearance: /
• Density: 1.44±0.1 g/cm3(Predicted)
• PKA: 3.76±0.10(Predicted)
• CAS DataBase Reference: 1-(3,4-dichlorobenzyl)-1H-pyrazol-3-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4-dichlorobenzyl)-1H-pyrazol-3-amine(895929-56-3)
• EPA Substance Registry System: 1-(3,4-dichlorobenzyl)-1H-pyrazol-3-amine(895929-56-3)

Safety Data

• Hazardous Substances Data: 895929-56-3(Hazardous Substances Data)

Usage

Uses

Used in Antimicrobial Applications:
1-(3,4-dichlorobenzyl)-1H-pyrazol-3-amine is used as an antimicrobial agent for its potential to combat various microorganisms, including bacteria and fungi. Its chemical structure allows it to interfere with essential cellular processes in these organisms, thereby inhibiting their growth and proliferation.
Used in Pharmaceutical Industry:
1-(3,4-dichlorobenzyl)-1H-pyrazol-3-amine is used as a building block in the pharmaceutical industry for the synthesis of other organic compounds with potential therapeutic applications. Its unique chemical properties make it a valuable component in the development of new drugs and medications.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(3,4-dichlorobenzyl)-1H-pyrazol-3-amine is used as a starting material for the development of new pesticides and other agricultural chemicals. Its ability to target specific pests and pathogens can contribute to the creation of more effective and targeted pest control solutions.
Used in Materials Science:
1-(3,4-dichlorobenzyl)-1H-pyrazol-3-amine is used as a component in the field of materials science, particularly in the development of novel polymers and functional materials. Its unique chemical structure can be leveraged to create materials with specific properties, such as enhanced strength, durability, or chemical resistance.

Upstream product

• 1003011-48-0 1-(3,4-dichloro-benzyl)-3-nitro-1H-pyrazole 
• 1820-80-0 3-aminopyrazole 
• 18880-04-1 3,4-dichlorobenzyl bromide 

Relevant articles and documents

Design, synthesis and biological evaluation of spiropyrazolopyridone derivatives as potent dengue virus inhibitors

The effective treatment for dengue virus infection continues to be a challenge. We herein reported our continued SAR exploration on the spiropyrazolopyridone scaffold. Introducing different substituents at the 3?- or 5?-site of the pyrazolopyridone core or moving the benzyl chain to the adjacent nitrogen led to a significant loss of potency on DENV-2. While a narrow range of substitutions were tolerated at the para-position of the phenyl ring, di-substitution on the phenyl ring is beneficial for DENV-2 potency and has variable influences on DENV-3 potency depending on the exact compound. Among these molecules, compounds 22 (JMX0376) with 4-chloro-3-fluorobenzyl and 24 (JMX0395) with 2,4-bis(trifluoromethyl)benzyl showed the most potent and broadest inhibitory activities against DENV-1 to ?3 with nanomolar to low micromolar EC50 values.

Pyrazole glucokinase activators

Disclosed herein are pyrazole glucokinase activators of the formula (I) useful for the treatment of metabolic diseases and disorders, preferably diabetes mellitus.