- Pyrimido azacyclo compound and application thereof
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The invention discloses a pyrimido azacyclo compound represented by a general formula I, and a pharmaceutically acceptable salt thereof, and relates to the technical field of organic chemistry, wherein substituent groups X and Ar are defined in the specification. The invention also relates to application of the compound represented by the general formula I and the pharmaceutically acceptable saltthereof in medicines for treating diseases caused by abnormal high expression of URAT1, particularly in preparation of medicines for treating and/or preventing gout, wherein the general formula I is defined in the specification.
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Paragraph 0043; 0045; 0048-0049
(2020/07/13)
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- Inhibitor containing fused ring derivative as well as preparation method and application thereof
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The invention relates to an inhibitor containing fused ring derivative as well as a preparation method and application thereof. Particularly, the invention relates to a compound as shown in a generalformula (I), a preparation method thereof, a pharmaceuti
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Paragraph 0316; 0323-0326
(2020/12/30)
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- The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5- a]pyridin-6-yl)amino]-9-(tetrahydro-2 H-pyran-4-yl)-7,9-dihydro-8 H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor
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DNA-PK is a key component within the DNA damage response, as it is responsible for recognizing and repairing double-strand DNA breaks (DSBs) via non-homologous end joining. Historically it has been challenging to identify inhibitors of the DNA-PK catalyti
- Goldberg, Frederick W.,Finlay, M. Raymond V.,Ting, Attilla K. T.,Beattie, David,Lamont, Gillian M.,Fallan, Charlene,Wrigley, Gail L.,Schimpl, Marianne,Howard, Martin R.,Williamson, Beth,Vazquez-Chantada, Mercedes,Barratt, Derek G.,Davies, Barry R.,Cadogan, Elaine B.,Ramos-Montoya, Antonio,Dean, Emma
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supporting information
p. 3461 - 3471
(2020/02/04)
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- Synthesis and biological evaluation of pyrimidine derivatives as novel human Pin1 inhibitors
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Pin1 (Protein interacting with NIMA1) is a cis–trans isomerase and promotes the amide bond rotation of phosphoSer/Thr-Pro motifs in its substrates. Inhibition of Pin1 might be a novel strategy for developing anticancer agents. Herein, a series of pyrimidi
- Cui, Guonan,Jin, Jing,Chen, Hualong,Cao, Ran,Chen, Xiaoguang,Xu, Bailing
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supporting information
p. 2186 - 2197
(2018/03/28)
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- Compounds with antiulcer and antisecretory activity. III. N-substituted imidazolones condensed with nitrogen-containing heteroaromatic rings
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The syntheses of imidazo[4,5-b]pyridin-2-ones and -thiones, imidazo [4,5-c]pyridin-2-ones and 7,9-dihydro-8H-purin-8-ones arylated (or heteroarylated) at an imidazolone nitrogen are reported. Only some compounds of the first series have marked antisecreto
- Bianchi,Butti,Rossi,et al.
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p. 501 - 506
(2007/10/02)
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