89660-19-5Relevant articles and documents
The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5- a]pyridin-6-yl)amino]-9-(tetrahydro-2 H-pyran-4-yl)-7,9-dihydro-8 H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor
Goldberg, Frederick W.,Finlay, M. Raymond V.,Ting, Attilla K. T.,Beattie, David,Lamont, Gillian M.,Fallan, Charlene,Wrigley, Gail L.,Schimpl, Marianne,Howard, Martin R.,Williamson, Beth,Vazquez-Chantada, Mercedes,Barratt, Derek G.,Davies, Barry R.,Cadogan, Elaine B.,Ramos-Montoya, Antonio,Dean, Emma
, p. 3461 - 3471 (2020/02/04)
DNA-PK is a key component within the DNA damage response, as it is responsible for recognizing and repairing double-strand DNA breaks (DSBs) via non-homologous end joining. Historically it has been challenging to identify inhibitors of the DNA-PK catalyti
Inhibitor containing fused ring derivative as well as preparation method and application thereof
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, (2020/12/30)
The invention relates to an inhibitor containing fused ring derivative as well as a preparation method and application thereof. Particularly, the invention relates to a compound as shown in a generalformula (I), a preparation method thereof, a pharmaceuti
Identification of polo-like kinase 1 inhibitors using structure-based molecular design
Nam, Ky-Youb,Kang, Ju Hee,Tai No, Kyoung,Ahn, Soon Kil
, p. 1929 - 1930 (2014/11/08)
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