89660-19-5

Upstream product

• 62-53-3 aniline 
• 54748-09-3 2-chloro-5-nitro-N-phenylpyrimidin-4-amine 

Downstream Products

• 89743-87-3 2-chloro-7-methyl-9-phenyl-7,9-dihydro-8H-purin-8-one 
• 89660-30-0 2-chloro-9-phenyl-7,9-dihydro-8H-purin-8-one 
• 118807-48-0 2-chloro-9-phenyl-9H-purine 
• 129006-43-5 (8,9-Diphenyl-9H-purin-2-yl)-phenyl-methanone 
• 129006-37-7 8,9-Diphenyl-9H-purine-2-carbonitrile 
• 118807-56-0 ethyl α-cyano-9-phenyl-9H-purine-2-acetate 
• 118807-57-1 α,9-diphenyl-9H-purine-2-acetonitrile 
• 118807-62-8 2-(9-phenyl-9H-purin-2-yl)cyclohexanone 
• 118807-54-8 9-phenyl-2-piperidino-9H-purine 
• 118807-51-5 2-phenoxy-9-phenyl-9H-purine 
• 118807-52-6 2-(methylsulfonyl)-9-phenyl-9H-purine 
• 118807-61-7 3-(9-phenyl-9H-purin-2-yl)-2-butanone 
• 118807-53-7 2-butylamino-9-phenyl-9H-purine 
• 118807-60-6 1-(9-phenyl-9H-purin-2-yl)-2-propanone 

Relevant academic research and scientific papers

Pyrimido azacyclo compound and application thereof

The invention discloses a pyrimido azacyclo compound represented by a general formula I, and a pharmaceutically acceptable salt thereof, and relates to the technical field of organic chemistry, wherein substituent groups X and Ar are defined in the specification. The invention also relates to application of the compound represented by the general formula I and the pharmaceutically acceptable saltthereof in medicines for treating diseases caused by abnormal high expression of URAT1, particularly in preparation of medicines for treating and/or preventing gout, wherein the general formula I is defined in the specification.

Inhibitor containing fused ring derivative as well as preparation method and application thereof

The invention relates to an inhibitor containing fused ring derivative as well as a preparation method and application thereof. Particularly, the invention relates to a compound as shown in a generalformula (I), a preparation method thereof, a pharmaceuti

The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5- a]pyridin-6-yl)amino]-9-(tetrahydro-2 H-pyran-4-yl)-7,9-dihydro-8 H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor

DNA-PK is a key component within the DNA damage response, as it is responsible for recognizing and repairing double-strand DNA breaks (DSBs) via non-homologous end joining. Historically it has been challenging to identify inhibitors of the DNA-PK catalyti

Synthesis and biological evaluation of pyrimidine derivatives as novel human Pin1 inhibitors

Pin1 (Protein interacting with NIMA1) is a cis–trans isomerase and promotes the amide bond rotation of phosphoSer/Thr-Pro motifs in its substrates. Inhibition of Pin1 might be a novel strategy for developing anticancer agents. Herein, a series of pyrimidi

Compounds with antiulcer and antisecretory activity. III. N-substituted imidazolones condensed with nitrogen-containing heteroaromatic rings

The syntheses of imidazo[4,5-b]pyridin-2-ones and -thiones, imidazo [4,5-c]pyridin-2-ones and 7,9-dihydro-8H-purin-8-ones arylated (or heteroarylated) at an imidazolone nitrogen are reported. Only some compounds of the first series have marked antisecreto