- THERAPEUTIC COMPOUNDS AND METHODS TO TREAT INFECTION
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Disclosed herein are compounds of formula (I), or a salt thereof and compositions comprising compounds of formula I that exhibit antibacterial activities, when tested alone and/or in combination with a bacterial efflux pump inhibitor. Also disclosed are methods of treating or preventing a bacterial infection in an animal comprising administering to the animal a compound of formula I alone or in combination with the administration of a bacterial efflux pump inhibitor.
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- NEW ARYLALKENYLPROPARGYLAMINE DERIVATIVES EXHIBITING NEUROPROTECTIVE ACTION FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
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The invention relates to novel arylalkenylpropargylamine derivatives of general formula (I) or enantiomers or diastereomers thereof or salts, optionally pharmaceutically acceptable salts, or solvates of any of these. The compounds can be used in treating or preventing a disease or condition in a mammal related to monoamine oxidase dysfunction, especially in neurodegenerative diseases, e.g. Parkinson's disease, Alzheimer's disease or Huntington's disease.
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Page/Page column 27; 59
(2015/06/25)
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- Traceless Fischer indole synthesis on the solid phase
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The Fischer indole synthesis using polymer-bound hydrazines is employed as the key step for the development of a traceless indole synthesis on a solid support.
- Rosenbaum, Claudia,Katzka, Catherine,Marzinzik, Andreas,Waldmann, Herbert
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p. 1822 - 1823
(2007/10/03)
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- SYNTHESIS OF 2-ACYLINDOLES FROM α-(N-ISATINYL) KETONES
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2-Acylindoles were synthesized by the recyclization of N-phenacyl- and N-acetonylisatins in alkaline medium and the decarboxylation of 2-acylindolyl-3-carboxylic acids or their salts in basic or neutral media.
- Gorgos, V. I.,Zorin, L. M.,Zhungietu, G. I.,Rekhter, M. A.
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p. 1179 - 1181
(2007/10/02)
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