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Usage

Uses

Used in Pharmaceutical Industry:
1-(5-bromo-1H-indol-2-yl)Ethanone is used as a key intermediate in the synthesis of biologically active molecules for the pharmaceutical industry. Its interaction with various biological targets allows for the development of potential pharmaceuticals with diverse applications.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(5-bromo-1H-indol-2-yl)Ethanone is utilized as a starting material for the creation of compounds with pesticidal, herbicidal, or fungicidal properties. Its versatility in chemical reactions enables the development of new agrochemicals to address various agricultural needs.
Used in Material Science:
1-(5-bromo-1H-indol-2-yl)Ethanone is also used in material science for the development of novel materials with specific properties. The bromine substitution in the molecule can alter the reactivity and characteristics of the resulting materials, making them suitable for various applications in this field.

Upstream product

• 431-03-8 dimethylglyoxal 
• 589-21-9 (4-bromophenyl)hydrazine 
• 1016481-05-2 5-bromo-1H-indole-2-carboxylic acid N-methoxy-N-methyl amide 
• 917-54-4 methyllithium 
• 7254-19-5 5-bromo-2-indolecarboxylic acid 
• 75822-35-4 5-bromo-1-(2-oxopropyl)-2,3-dihydro-1H-indole-2,3-dione 
• 79570-74-4 2-Acetyl-5-bromo-1H-indole-3-carboxylic acid 

Downstream Products

• 1373439-01-0 1-(5-phenyl-1H-indol-2-yl)ethanone 
• 1373438-66-4 (E)-N'-(1-(5-azido-1H-indol-2-yl)ethylidene)-5-bromo-2-(prop-2-ynyloxy)benzohydrazide 
• 1373438-17-5 (E)-5-bromo-N'-(1-(5-bromo-1H-indol-2-yl)ethylidene)-2-hydroxybenzohydrazide 
• 1373438-16-4 (E)-5-bromo-2-hydroxy-N'-(1-(5-phenyl-1H-indol-2-yl)ethylidene)benzohydrazide 
• 1350889-05-2 (E/Z)-5-bromo-N'-(1-(5-bromo-1-methyl-1H-indol-2-yl)ethylidene)-2-hydroxybenzohydrazide 
• 96286-10-1 2-<1-(dimethylamino)ethyl>indole 

Relevant academic research and scientific papers

THERAPEUTIC COMPOUNDS AND METHODS TO TREAT INFECTION

Disclosed herein are compounds of formula (I), or a salt thereof and compositions comprising compounds of formula I that exhibit antibacterial activities, when tested alone and/or in combination with a bacterial efflux pump inhibitor. Also disclosed are methods of treating or preventing a bacterial infection in an animal comprising administering to the animal a compound of formula I alone or in combination with the administration of a bacterial efflux pump inhibitor.

NEW ARYLALKENYLPROPARGYLAMINE DERIVATIVES EXHIBITING NEUROPROTECTIVE ACTION FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

The invention relates to novel arylalkenylpropargylamine derivatives of general formula (I) or enantiomers or diastereomers thereof or salts, optionally pharmaceutically acceptable salts, or solvates of any of these. The compounds can be used in treating or preventing a disease or condition in a mammal related to monoamine oxidase dysfunction, especially in neurodegenerative diseases, e.g. Parkinson's disease, Alzheimer's disease or Huntington's disease.

Traceless Fischer indole synthesis on the solid phase

The Fischer indole synthesis using polymer-bound hydrazines is employed as the key step for the development of a traceless indole synthesis on a solid support.

SYNTHESIS OF 2-ACYLINDOLES FROM α-(N-ISATINYL) KETONES

2-Acylindoles were synthesized by the recyclization of N-phenacyl- and N-acetonylisatins in alkaline medium and the decarboxylation of 2-acylindolyl-3-carboxylic acids or their salts in basic or neutral media.