89807-04-5

Basic information

• Product Name: D-(~11~C)methionine
• CAS NO: 89807-04-5
• Molecular Formula: C₄¹¹CH₁₁NO₂S
• Molecular Weight: 148.2121
• Mol File: 89807-04-5.mol

Chemical Properties

• Density: 1.206g/cm³
• Refractive Index: 1.53
• CAS DataBase Reference: D-(~11~C)methionine(CAS DataBase Reference)
• NIST Chemistry Reference: D-(~11~C)methionine(89807-04-5)
• EPA Substance Registry System: D-(~11~C)methionine(89807-04-5)

Safety Data

• Hazardous Substances Data: 89807-04-5(Hazardous Substances Data)

Upstream product

• 54245-42-0 [11C]methyl iodide 
• 2338-04-7 L-homocysteine thiolactone 
• 31828-68-9 L-homocysteine thiolactone hydrochloride 
• 145577-00-0 [11C]methyl triflate 
• 1120-77-0 D-homocysteine thiolactone hydrochloride 

Relevant articles and documents

Highlighting the versatility of the Tracerlab synthesis modules. Part 2: Fully automated production of [11C]-labeled radiopharmaceuticals using a Tracerlab FXC-Pro

The field of radiochemistry is moving toward exclusive use of automated synthesis modules for production of clinical radiopharmaceutical doses. Such a move not only comes with many advantages but also presents radiochemists with the challenge of re-configuring synthesis modules for production of radiopharmaceuticals that require non-conventional radiochemistry while maintaining full automation. Herein, we continue our series of articles showcasing the versatility of the Tracerlab FX synthesis modules by presenting straightforward, fully automated methods for preparing a range of carbon-11 labeled radiopharmaceuticals using a Tracerlab FXC-Pro. Strategies for production of [11C]acetate, [11C]carfentanil, [ 11C]choline, [11C]3-amino-4-[2-[(di(methyl)amino)methyl] phenyl]sulfanylbenzonitrile ([11C]DASB), (+)-a-[11C] dihydroterabenazine ([11C]DTBZ), [11C]flumazenil ([ 11C]FMZ), meta-hydroxyephedrine ([11C]HED), [ 11C]methionine, [11C]PBR28, [11C]Pittsburgh Compound B ([11C]PiB), 1-[11C]methylpiperidin-4-yl propionate ([11C]PMP), and [11C]raclopride are presented.

High efficiency preparation of L-[S-methyl-11C]methionine by on-column [11C]methylation on C18 Sep-Pak

A novel approach to the synthesis of L-[S-methyl-11C]methionine, (11C]MET) is described which involves a commercial C18 Sep-Pak Plus as a solid-phase support material for the [11C]methylation step. The present method, which uses [11C]CH3I produced by the classical LiAlH4/HI route, supplies [11C]MET ready for injection within 11 min from the end of bombardment (EOB) with a radiochemical yield, decay corrected at EOB, of 78% and a radiochemical purity at the end of synthesis (EOS) higher than 99%. The required setup is extremely simple and easy to automate and can be reset for a further synthesis within few minutes. Moreover, due to its versatility, the method can be utilized for the production of other radiopharmaceuticals requiring a simple [11C]methylation.

Methylation of amide and thiol functions with [11C]methyl triflate, as exemplified by [11C]NMSP, [11C]flumazenil and [11C]methionine

[11C]Methyl triflate was compared with [11C]methyl iodide as a labelled precursor in the synthesis of PET radioligands through 11C- methylation of amide and thiol functions. [11C]NMSP [11C]flumazenil

Supercritical fluid synthesis and on-line preparative supercritical fluid chromatography of 11C-labelled compounds in supercritical ammonia

An automated supercritical fluid synthesis (SFS) system, designed for reaction and on-line preparative supercritical fluid chromatography (SFC) of 11C-labelled (t1/2 = 20.3 min) compounds in supercritical ammonia, is described. The s