31828-68-9

Usage

Uses

Used in Pharmaceutical Industry:
L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE is used as a precursor for the preparation of substituted homocysteine analogs, which act as inhibitors of peptidylglycine α-amidating monooxygenase (PAM). This enzyme plays a crucial role in the post-translational processing of peptide hormones, and its inhibition can lead to the development of therapeutic agents for various diseases.
Additionally, L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE is used in the synthesis of (mercaptoacyl)alanylprolines, which are potent metalloprotease inhibitors. Metalloproteases are a class of enzymes involved in various physiological processes, including tissue remodeling, inflammation, and cell signaling. Inhibition of these enzymes can be beneficial in treating conditions such as arthritis, cancer, and neurodegenerative diseases.

Biochem/physiol Actions

L-Homocysteine thiolactone, an amine reactive agent, is used to study post-translational modification of proteins, especially at lysine residues.

InChI:InChI=1/C4H7NOS.ClH/c5-3-1-2-7-4(3)6;/h3H,1-2,5H2;1H/t3-;/m0./s1

Upstream product

• 1051970-96-7 S-HCT madelate 
• 1051970-97-8 S-HCT ditoluoyltartrate 
• 6038-19-3 3-aminodihydrothiophen-2(3H)-one hydrochloride 

Downstream Products

• 38869-92-0 (3S,6S)-3,6-bis(2-sulfanylethyl)piperazine-2,5-dione 
• 60305-58-0 L-[S-methyl-11C]methionine 
• 944389-99-5 N-(p-nitrobenzylidene)-2-oxotetrahydro-3-thiophenine 
• 6038-19-3 3-aminodihydrothiophen-2(3H)-one hydrochloride 
• 202284-85-3 (S)-N-butyryl homocysteine thiolactone 
• 56-88-2 L-cystathionine 
• 111109-99-0 (S)-2-amino-4-((((2S,3S,4R,5S)-5-(6-(benzylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)thio)butanoic acid 
• 1341220-53-8 (S)-2-amino-4-((((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-bis(benzyloxy)tetrahydrofuran-2-yl)methyl)thio)butanoic acid 
• 1341220-52-7 (S)-2-amino-4-((((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-(benzyloxy)-3-hydroxytetrahydrofuran-2-yl)methyl)thio)butanoic acid 
• 1341220-51-6 (S)-2-amino-4-((((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-(benzyloxy)-4-hydroxytetrahydrofuran-2-yl)methyl)thio)butanoic acid 
• 66608-10-4 N-6-chloronicotinoyl-d,l-homocysteine thiolactone 
• 6027-13-0 L-homocysteine 
• 89807-04-5 D-[S-methyl-11C]methionine 
• 1595282-56-6 (S)-4-((3-((6-amino-9H-purin-9-yl)methyl)phenyl)methylthio)-2-aminobutanoic acid 

Relevant academic research and scientific papers

COMPOSITIONS AND METHODS FOR CYCLOFRUCTANS AS SEPARATION AGENTS

The present invention relates to derivatized cyclofructan compounds, compositions comprising derivatized cyclofructan compounds, and methods of using compositions comprising derivatized cyclofructan compounds for chromatographic separations of chemical species, including enantiomers. Said compositions may comprise a solid support and/or polymers comprising derivatized cyclofructan compounds.

Process for the resolution of homocysteine-thiolactone

The present invention relates to a process for the preparation of enantiomerically pure homocysteine-γ-thiolactone comprising optical resolution of racemic homocysteine-γ-thiolactone (I) with a chiral organic acid wherein one isomer is recovered as diastereomeric salt with the organic acid and the other isomer remaining in the mother liquor is submitted to racemisation with a catalytic amount of an aromatic aldehyde and submitted again to optical resolution with the same chiral organic acid.