- A novel bridgehead azocine. The end of a controversy
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A novel bridgehead azocine 4 has been obtained from aminopyran 1 and benzylidinemalononitrile 6. The structure of 4 was confirmed by X-ray diffraction.
- Martin, Nazario,Quinteiro, Margarita,Seoane, Carlos,Albert, Armando,Cano, Felix H.,Abramovitch, Rudolph A.
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Read Online
- 5-Acetyl-2-amino-6-methyl-4-phenyl-4H-pyran-3-carbonitrile and 2-amino-5-benzoyl-6-methyl-4-phenyl-4H-pyran-3-carbonitrile acetonitrile solvate
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The syntheses, X-ray structural investigations and calculations of the conformational preferences of the carbonyl substituent with respect to the pyran ring have been carried out for the two title compounds, viz. C 15H14N2
- Nesterov, Vladimir N.,Wiedenfeld, David J.,Nesterova, Svitlana V.,Hastings, Lucas F.
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Read Online
- Ferric Sulfasalazine Sulfa Drug Complex Supported on Cobalt Ferrite Cellulose; Evaluation of Its Activity in MCRs
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Abstract: The green and nano catalyst was simply prepared through the reaction of ferric sulfasalazine with nanomaterial CoFe2O4-cellulose as a magnetic biopolymer surface. This novel heterogeneous organometallic catalyst was charact
- Rostamizadeh, Shahnaz,Daneshfar, Zahra,Khazaei, Ali
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p. 2091 - 2114
(2020/01/31)
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- Immobilized piperazine on the surface of graphene oxide as a heterogeneous bifunctional acid-base catalyst for the multicomponent synthesis of 2-amino-3-cyano-4: H -chromenes
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Immobilized piperazine on the surface of graphene oxide (piperazine-GO) is synthesized and characterized by different methods such as FT-IR, solid-state 29Si{1H} and 13C{1H} CP/MAS NMR, elemental analysis, TGA, TEM, FE-SEM, XPS, and TPD. Subsequently, it is used as a heterogeneous bifunctional acid-base catalyst for the efficient multicomponent reaction of malononitrile, different active compounds containing enolizable C-H bonds and various aryl/alkyl aldehydes in aqueous ethanol. A wide variety of 2-amino-3-cyano-4H-chromenes are synthesized in the presence of this heterogeneous catalyst in good to high yields and with short reaction times. The catalyst is easily separated and reused for at least six times without significant loss of activity. The acidic nature of GO improves the catalytic activity of the supported piperazine and also provides heterogeneity to the catalyst. Use of aqueous ethanol as a green solvent, high turnover numbers (TON), facile catalyst recovery and reuse, simple work-up and generality of the method make this protocol an environmentally benign procedure for the synthesis of the title heterocycles.
- Jahanshahi, Roya,Khazaee, Asma,Sansano, José Miguel,Skibsted, J?rgen,Sobhani, Sara
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p. 4604 - 4616
(2020/08/10)
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- Biocatalytic tandem multicomponent reactions for one-pot synthesis of 2-Amino-4H-Pyran library and in vitro biological evaluation
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A simple, effective and ecofriendly biocatalytic method has been developed to construct 2-amino-4H-pyrans via tandem multi-component reaction (MCR) of aldehyde, malononitrile and ethyl acetoacetate in one pot. The catalytic activity of lipases in differen
- Gong, Qing-Tian,Liu, Yan-Hong,Wang, Na,Wang, Yun,Yang, Zeng-Jie,Yu, Xiao-Qi,Yu, Yuan
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- Efficient Three-Component One-Pot Synthesis of 4H-Pyrans
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Clean, practical, and efficient electrochemical synthesis of pharmaceutically relevant 4H-pyran derivatives by one-pot three-component combination of an aryl aldehyde, malononitrile, and a dicarbonyl compoundis developed. The synthesis is performed in eth
- Malviya,Kala,Sharma,Singh
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p. 686 - 693
(2019/07/17)
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- Synthesis method of 2-amino-4H-pyran and derivative of 2-amino-4H-pyran
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The invention discloses a synthesis method of 2-amino-4H-pyran and a derivative of the 2-amino-4H-pyran. According to the method, candida rugosa lipase (CRL) is adopted as a catalyst to initiate a tandem MCR reaction, and 2-amino-4H-pyran is synthesized i
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Paragraph 0046-0049
(2019/10/01)
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- Organocatalytic mediated green approach: A versatile new L-valine promoted synthesis of diverse and densely functionalized 2-amino-3-cyano-4H-pyrans
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The discovery of a new L-valine promoted facile and versatile green synthesis of diversified 2-amino-3-cyano-4H-pyrans using a one pot multicomponent-tandem reaction of aromatic aldehydes, malononitrile, and diverse electron-rich enolizable carbonyl compo
- Tiwari, Jyoti,Singh, Swastika,Saquib, Mohammad,Tufail, Fatima,Sharma, Amit Kumar,Singh, Shailesh,Singh, Jaya,Singh, Jagdamba
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supporting information
p. 188 - 196
(2018/01/01)
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- Magnetic Graphitic Carbon Nitride-Catalyzed Highly Efficient Construction of Functionalized 4 H -Pyrans
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A high-yielding, practical, efficient, and environmentally benign one-pot multicomponent synthesis of functionalized 2-amino-4 H -pyrans from β-dicarbonyl compounds, malononitrile, and aldehydes is presented. Good to excellent yields were obtained under m
- Azizi, Najmedin,Ahooie, Tahereh Soleymani,Hashemi, Mohammad Mahmodi,Yavari, Issa
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p. 645 - 649
(2018/01/17)
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- Preparation of a superior liquid catalyst by hybridization of three solids of nanoZnO, urea, and choline chloride for Knoevenagel-based reactions
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Abstract: The complex catalyst of [ZnClO.urea]?[Ch.urea]+ has been prepared by dissolving of nanoZnO in choline chloride:2urea at 50 °C. The concentration of [ZnClO.urea]? in the given liquid is 19,987 ppm and 10.5 times h
- Tamaddon, Fatemeh,Azadi, Davood
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p. 2077 - 2086
(2017/09/13)
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- Group-assisted purification (GAP) chemistry for dihydrofurans: Water as a medium for catalyst free synthesis in a one pot four component reaction
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A simple, catalyst free, water mediated, one pot four component, green protocol was developed for title compounds 7 starting from aromatic aldehydes (1), malononitrile (2), 1,3-diones (3) and N-chlorosuccinimide (NCS) in a sequential addition reaction at
- Chennapuram, Madhu,Emmadi, Narender Reddy,Bingi, Chiranjeevi,Nanubolu, Jagadeesh Babu,Atmakur, Krishnaiah
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p. 3237 - 3246
(2014/06/10)
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- Meglumine: A novel and efficient catalyst for one-pot, three-component combinatorial synthesis of functionalized 2-amino-4 H-pyrans
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An efficient one-pot synthesis of functionalized 2-amino-4H-pyrans by a meglumine-catalyzed three-component reaction has been developed. A broad range of substrates including aromatic and heteroaromatic aldehydes, isatin derivatives, and acenaphthenequino
- Guo, Rui-Yun,An, Zhi-Min,Mo, Li-Ping,Wang, Rui-Zhi,Liu, Hong-Xia,Wang, Shu-Xia,Zhang, Zhan-Hui
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p. 557 - 563
(2013/12/04)
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- Efficient deep eutectic solvents catalyzed synthesis of pyran and benzopyran derivatives
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An ecofriendly one-pot multicomponent reaction of 1,3-dicarbonyl compounds, aldehydes, and malononitrile was carried out in a different deep eutectic solvent (DES) based on choline chloride, to synthesize highly functionalized benzopyran and pyran derivat
- Azizi, Najmedin,Dezfooli, Sahar,Khajeh, Meysam,Hashemi, Mohammad Mahmoudi
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- Nano crystalline ZnO catalyzed one pot multicomponent reaction for an easy access of fully decorated 4H-pyran scaffolds and its rearrangement to 2-pyridone nucleus in aqueous media
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A green and highly efficient protocol has been developed for the synthesis of 4H-pyran scaffolds installing a one-pot three-component coupling reaction of an aldehyde, malononitrile, and a 1,3-diketo compound using nano structured ZnO as the catalyst in a
- Bhattacharyya, Pranabes,Pradhan, Koyel,Paul, Sanjay,Das, Asish R.
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supporting information; experimental part
p. 4687 - 4691
(2012/09/05)
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- Organocatalysis in synthesis: L-proline as an enantioselective catalyst in the synthesis of pyrans and thiopyrans
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The multicomponent reaction (MCR) of aromatic aldehydes 1 and malononitrile (2) with active methylenes 5a-h in the presence of L-proline produced pyrans and thiopyrans 6a-h stereospecifically and in good yields. Moreover a novel MCR of ethyl propiolate (8) with 1 and 2 in the presence of L-proline to afford (R)-polysubstituted pyran is also reported. X-ray structures, e.e. and optical activity of the synthesized compounds indicated that L-proline as a catalyst is responsible for the observed enantioselectivity in the studied reactions.
- Hilmy Elnagdi, Noha M.,Al-Hokbany, Noura Saad
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experimental part
p. 4300 - 4312
(2012/07/28)
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- Baker's yeast catalyzed one-pot three-component synthesis of polyfunctionalized 4H-pyrans
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Baker's yeast catalyzed one-pot three-component cyclocondensation of aryl aldehydes, malononitrile, and b-dicarbonyls in organic medium has been carried out to obtain polyfunctionalized 4H-pyrans. The reaction has been carried out at room temperature in o
- Pratap, Umesh R.,Jawale, Dhanaji V.,Netankar, Prashant D.,Mane, Ramrao A.
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experimental part
p. 5817 - 5819
(2011/12/03)
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- Study on the Pd/C-catalyzed (retro-)Michael addition reaction of activated methylene compounds to electron-poor styrenes
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Palladium on carbon (10 % Pd/C) efficiently catalyzes the (retro-)Michael addition of activated methylene compounds 2a-d, such as malononitrile (2b), to mono- and doubly activated styrenes 1a-h to give the adducts 3a-l. The scope and limitations are described. The Knoevenagel condensation reaction of benzaldehyde and 2b or ethyl cyanoacetate (2c) is also catalyzed by 10 % Pd/C. In these cases the Michael adducts can even be prepared in a three-component reaction. A mechanism, with as first step the oxidative addition of 2a-d to Pd0, is proposed. Palladium on carbon (10 % Pd catalyzes the (retro-)Michael addition of activated methylene compounds 2a-d to mono- anddoubly activated styrenes. The scope and limitations of the reaction are described. A mechanism is proposed. Copyright
- Nikishkin, Nicolai I.,Huskens, Jurriaan,Verboom, Willem
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body text
p. 6820 - 6823
(2011/02/26)
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- Green Heterogeneous Catalysis: Chitosan and Nanoparticulated Magnesium Oxide as Ecofriendly Catalyses for Michael Addition
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HETEROGENEOUS ecofriendly base catalysis namely, chitosan and nanoparticulated MgO are promising new catalysis in Michael addition that can efficiency replace homogeneous polluting catalysts. Aminopyrancarbonitriles, pyranopyrazole, thiazolopyridines and chromenes can be obtained in ethanolic or methanolic chitosan or MgO in good yields.
- Elnajjar,Attala,Elkholy
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p. 891 - 901
(2013/05/22)
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- Tetramethylguanidine-[bmim][BF4]. An efficient and recyclable catalytic system for one-pot synthesis of 4H-pyrans
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A clean and efficient method for the synthesis of 4H-pyran derivatives through the one-pot condensation of aromatic aldehydes, malononitriles, and β-dicarbonyl compounds, using guanidine base tetramethylguanidine in [bmim] [BF4] ionic liquid as
- Peng, Yanqing,Song, Gonghua,Huang, Feifei
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p. 727 - 731
(2007/10/03)
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- Efficient and convenient method for the synthesis of poly functionalised 4H-pyrans
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An efficient single-pot method for the synthesis of polyfunctionalized 4H-pyrans using alkaline metal fluoride as a catalyst is described.
- Lingaiah,Reddy, G. Venkat,Yakaiah,Narsaiah,Reddy,Yadla,Rao, P. Shanthan
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p. 4431 - 4437
(2007/10/03)
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- REACTIONS OF SIX-MEMBERED HETEROCYCLIC β-ENAMINONITRILES WITH ELECTROPHILIC REAGENTS
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The nitriles I reacted with acetylacetone and with ethyl acetoacetate to afford 2-amino-3-cyano-4H-pyran derivatives.They reacted further to yield pyranopyridine derivatives.The reaction of V with acetylacetone afforded the pyridinethione VIII.This afford
- Zayed, Salem E.,Elmaged, Eiman I. Abou,Metwally, Saud A.,Elnagdi, Mohamed H.
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p. 2175 - 2182
(2007/10/02)
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- A CONVENIENT, ONE STEP SYNTHESIS OF PYRANOPYRIDINES
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A novel one step synthesis of pyranopyridines from malononitrile and unsaturated ketones is reported.The reaction mechanism is discussed and takes place through an intermediate monocyclic 4H-pyran.Several derivatives with different substitution pat
- Martin, Nazario,Seoane, Carlos,Soto, Jose L.
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p. 5861 - 5868
(2007/10/02)
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- Studies on Heterocyclic Enamines: New Syntheses of 4H-Pyranes, Pyranopyrazoles and Pyranopyrimidines
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The behaviour of several 2-amino-3-cyano-4H-pyran derivatives toward a variety of nucleophilic reagents is reported.
- Elnagdi, Mohamed Hilmy,Abdel-Motaleb, Ramadan Maawad,Mustafa, Mona,Zayed, Mohamed Foad,Kamel, Eman Moustafa
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p. 1677 - 1682
(2007/10/02)
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- ACTIVATED NITRILES IN HETEROCYCLIC SYNTHESIS: A NEW APPROACH FOR THE SYNTHESIS OF PYRAN DERIVATIVES
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The reaction of cinnamonitriles with acetylacetone end ethyl acetoacetate is reported.Several new polyfunctional pyrans could be prepared.Spectral data of the synthesized products is reported.
- Ibrahim, Nadia S.
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p. 935 - 938
(2007/10/02)
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- SYNTHESIS OF HETEROCYCLIC COMPOUNDS. XXXVI. PREPARATION OF ALKYL SUBSTITUTED PYRANCARBONITRLES.
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The cyclization of the ketonitriles obtained from the reaction of suitably substituted propenones with propanedinitrile leads to alkyl substituted 4H-pyrans.Some of the starting propenones had to be prepared by base promoted opening of an isoxazole ring in the presence of an aldehyde.An exception to the general synthesis is also reported.
- Soto, Jose L.,Seoane, Carlos,Martin, Nazario,Quinteiro, Margarita
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