89809-89-2

Usage

InChI:InChI=1/C15H14N2O2/c1-9(18)13-10(2)19-15(17)12(8-16)14(13)11-6-4-3-5-7-11/h3-7,14H,17H2,1-2H3

Upstream product

• 2700-22-3 Benzylidenemalononitrile 
• 123-54-6 acetylacetone 
• 4335-90-4 3-benzylidene acetylacetone 
• 109-77-3 malononitrile 
• 100-52-7 benzaldehyde 
• 105-45-3 acetoacetic acid methyl ester 

Downstream Products

• 115041-50-4 5-Amino-3-acetyl-4,7-diphenyl-2-methyl-6,7-dihydro-4H-pyrano<2,3-b>pyridine-6,6-dicarbonitrile 
• 120811-07-6 3-acetyl-5-amino-6-cyano-2-methyl-6-methoxycarbonyl-4,7-diphenyl-6,7-dihydro-4H-pyrano<2,3-b>pyridine 
• 72568-47-9 2-amino-3-cyano-5-ethoxycarbonyl-6-methyl-4-phenyl-4H-pyran 
• 120811-09-8 3-acetyl-5-amino-7-(p-chlorophenyl)-6-cyano-2-methyl-6-methoxycarbonyl-4-phenyl-6,7-dihydro-4H-pyrano<2,3-b>pyridine 
• 116418-14-5 2,4-dimethyl-5-cyano-3-(1-phenyl-2-dicyanoethyl)-2H-pyran-6-one 
• 2700-22-3 Benzylidenemalononitrile 
• 60989-51-7 2-imino-4,6-dimethyl-2H-pyran-3-carbonitrile 
• 1610831-64-5 4-acetyl-2-cyano-5-methyl-3-phenyl-2,3-dihydrofuran-2-carboxamide 
• 107752-97-6 2-amino-7,7-dimethyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile 
• 81829-58-5 2-amino-5-benzoyl-4,6-diphenyl-4H-pyran-3-carbonitrile 
• 116418-07-6 2-amino-3-cyano-4-phenyl-5-(2-amino-3-cyano-4-phenyl-4H-pyran-6-yl)-6-methyl-4H-pyran 
• 81000-11-5 6-amino-1,4-dihydro-3-methyl-4-phenylpyrano[2,3-c]pyrazole-5-carbonitrile 
• 136773-44-9 3-Acetyl-5-amino-4,7-diphenyl-2-methyl-4H-pyrano<2,3-b>pyridine-6-carbonitrile 
• 116418-10-1 6-acetyl-4-N-benzoylamino-1,2-dihydro-7-methyl-5-phenyl-2-thioxo-5H-pyrano<2,3-d>pyrimidine 

Relevant academic research and scientific papers

A novel bridgehead azocine. The end of a controversy

A novel bridgehead azocine 4 has been obtained from aminopyran 1 and benzylidinemalononitrile 6. The structure of 4 was confirmed by X-ray diffraction.

5-Acetyl-2-amino-6-methyl-4-phenyl-4H-pyran-3-carbonitrile and 2-amino-5-benzoyl-6-methyl-4-phenyl-4H-pyran-3-carbonitrile acetonitrile solvate

The syntheses, X-ray structural investigations and calculations of the conformational preferences of the carbonyl substituent with respect to the pyran ring have been carried out for the two title compounds, viz. C 15H14N2

Ferric Sulfasalazine Sulfa Drug Complex Supported on Cobalt Ferrite Cellulose; Evaluation of Its Activity in MCRs

Abstract: The green and nano catalyst was simply prepared through the reaction of ferric sulfasalazine with nanomaterial CoFe2O4-cellulose as a magnetic biopolymer surface. This novel heterogeneous organometallic catalyst was charact

Immobilized piperazine on the surface of graphene oxide as a heterogeneous bifunctional acid-base catalyst for the multicomponent synthesis of 2-amino-3-cyano-4: H -chromenes

Immobilized piperazine on the surface of graphene oxide (piperazine-GO) is synthesized and characterized by different methods such as FT-IR, solid-state 29Si{1H} and 13C{1H} CP/MAS NMR, elemental analysis, TGA, TEM, FE-SEM, XPS, and TPD. Subsequently, it is used as a heterogeneous bifunctional acid-base catalyst for the efficient multicomponent reaction of malononitrile, different active compounds containing enolizable C-H bonds and various aryl/alkyl aldehydes in aqueous ethanol. A wide variety of 2-amino-3-cyano-4H-chromenes are synthesized in the presence of this heterogeneous catalyst in good to high yields and with short reaction times. The catalyst is easily separated and reused for at least six times without significant loss of activity. The acidic nature of GO improves the catalytic activity of the supported piperazine and also provides heterogeneity to the catalyst. Use of aqueous ethanol as a green solvent, high turnover numbers (TON), facile catalyst recovery and reuse, simple work-up and generality of the method make this protocol an environmentally benign procedure for the synthesis of the title heterocycles.

Biocatalytic tandem multicomponent reactions for one-pot synthesis of 2-Amino-4H-Pyran library and in vitro biological evaluation

A simple, effective and ecofriendly biocatalytic method has been developed to construct 2-amino-4H-pyrans via tandem multi-component reaction (MCR) of aldehyde, malononitrile and ethyl acetoacetate in one pot. The catalytic activity of lipases in differen

Efficient Three-Component One-Pot Synthesis of 4H-Pyrans

Clean, practical, and efficient electrochemical synthesis of pharmaceutically relevant 4H-pyran derivatives by one-pot three-component combination of an aryl aldehyde, malononitrile, and a dicarbonyl compoundis developed. The synthesis is performed in eth

Synthesis method of 2-amino-4H-pyran and derivative of 2-amino-4H-pyran

The invention discloses a synthesis method of 2-amino-4H-pyran and a derivative of the 2-amino-4H-pyran. According to the method, candida rugosa lipase (CRL) is adopted as a catalyst to initiate a tandem MCR reaction, and 2-amino-4H-pyran is synthesized i

Organocatalytic mediated green approach: A versatile new L-valine promoted synthesis of diverse and densely functionalized 2-amino-3-cyano-4H-pyrans

The discovery of a new L-valine promoted facile and versatile green synthesis of diversified 2-amino-3-cyano-4H-pyrans using a one pot multicomponent-tandem reaction of aromatic aldehydes, malononitrile, and diverse electron-rich enolizable carbonyl compo

Magnetic Graphitic Carbon Nitride-Catalyzed Highly Efficient Construction of Functionalized 4 H -Pyrans

A high-yielding, practical, efficient, and environmentally benign one-pot multicomponent synthesis of functionalized 2-amino-4 H -pyrans from β-dicarbonyl compounds, malononitrile, and aldehydes is presented. Good to excellent yields were obtained under m

Preparation of a superior liquid catalyst by hybridization of three solids of nanoZnO, urea, and choline chloride for Knoevenagel-based reactions

Abstract: The complex catalyst of [ZnClO.urea]?[Ch.urea]+ has been prepared by dissolving of nanoZnO in choline chloride:2urea at 50 °C. The concentration of [ZnClO.urea]? in the given liquid is 19,987 ppm and 10.5 times h