89854-22-8Relevant articles and documents
Synthesis and biological evaluation of 6-substituted purine and 9-β-D-ribofuranosyl purine analogues
Wang, Jun-Feng,Zhang, Liang-Ren,Yang, Zhen-Jun,Zhang, Li-He
, p. 1425 - 1429 (2004)
6-Substituted purine and 9-β-D-ribofuranosyl purine analogues were synthesized and their biological activities were evaluated. CD Spectra and thermal melting studies showed that compounds 8, 9, 10 could interact with RNA and DNA in solution. Compound 8 and 10 may bind with RNA single strand and interfere the formation of RNA duplex. Among of these compounds, compound 8 showed middle inhibition on the growth of HeLa cells (70.21%) and HL-60 cells (70.85%) at 10 μM. Comparing to the structures of these synthetic compounds, it may indicate that the sugar moiety and the 6-amino side chain of nucleoside 8 play an important role in the biological activities.
Synthesis of purines bearing functionalized C-substituents by the conjugate addition of nucleophiles to 6-vinylpurines and 6-ethynylpurines
Kuchar, Martin,Pohl, Radek,Votruba, Ivan,Hocek, Michal
, p. 5083 - 5098 (2007/10/03)
Purines bearing diverse β-substituted ethyl or vinyl groups in position 6 were prepared by the conjugate addition of N-, O- and S-nucleophiles to 6-vinylpurines or 6-ethynylpurines. The scope of this methodology was systematically studied. The addition of
