- SUBSTITUTED TRICYCLICS AND METHOD OF USE
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The present invention provides for compounds of formula (I) wherein X, Y, and R1 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sj?gren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
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Paragraph 1188
(2017/02/09)
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- Synthesis of pyrido[2,3-d]pyridazines and pyrazino[2,3-d]-pyridazines-novel classes of GABAA receptor benzodiazepine binding site ligands
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Novel syntheses of 2,3,8-trisubstituted pyrido[2,3-d]pyridazines and 2,3,5-trisubstituted pyrazino[2,3-d]pyridazines are described. Two complementary routes to pyrido[2,3-d]pyridazines were developed, the first of which began by constructing the pyridine
- Mitchinson, Andrew,Blackaby, Wesley P.,Bourrain, Sylvie,Carling, Robert W.,Lewis, Richard T.
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p. 2257 - 2260
(2007/10/03)
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- Pyrazino-pyridazine derivatives as ligands for gaba receptors
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A class of pyrazino[2,3-d]pyridazine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 5-position, a substituted alkoxy moiety at the 3-position, and a range of substituents at the 2-position, are selective ligands for GABAA receptors, in particular having high affinity for the α2 and/or α3 and/or α5 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, ceonvulsions and cognitive disorders.
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- Isoxazolo-[3,4-d]-pyridazin-7-(6H)-one as a potential substrate for new aldose reductase inhibitors
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The isoxazolo-[3,4-d]-pyridazin-7-(6H)-one (2) and its corresponding open derivatives 5-acetyl-4-amino-(4-nitro)-6-substituted-3(2H)pyridazinones (3, 4) were used as simplified substrates for the synthesis of new aldose reductase inhibitors with respect t
- Costantino, Luca,Rastelli, Giulio,Gamberini, M. Cristina,Giovannoni, M. Paola,Piaz, Vittorio Dal,Vianello, Paola,Barlocco, Daniela
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p. 1894 - 1900
(2007/10/03)
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