898736-02-2

Basic information

• Product Name: 2-[(3-fluorophenyl)methoxy]benzonitrile
• Synonyms: 2-[(3-fluorophenyl)methoxy]benzonitrile
• CAS NO: 898736-02-2
• Molecular Formula: C₁₄H₁₀FNO
• Molecular Weight: 227.2337032
• Mol File: 898736-02-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[(3-fluorophenyl)methoxy]benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(3-fluorophenyl)methoxy]benzonitrile(898736-02-2)
• EPA Substance Registry System: 2-[(3-fluorophenyl)methoxy]benzonitrile(898736-02-2)

Safety Data

• Hazardous Substances Data: 898736-02-2(Hazardous Substances Data)

Usage

Molecular structure

A benzene ring with a cyano group (C≡N) attached to it, and a methoxy group (OCH3) attached to a 3-fluorophenyl group.

Physical state

White to off-white solid at room temperature.

Solubility

Sparingly soluble in water, soluble in organic solvents such as ethanol and ether.

Uses

Commonly used in organic synthesis as a building block in the creation of various pharmaceuticals and agrochemicals.

Functional group

Nitrile derivative of 2-[(3-fluorophenyl)methoxy]benzaldehyde.

Reactivity

Often used as a reagent in chemical processes to introduce the benzonitrile functional group.

Biological activities

Of interest for its potential biological activities.

Upstream product

• 611-20-1 salicylonitrile 
• 456-42-8 m-fluorobenzyl chloride 

Relevant articles and documents

Ginger and its bioactive component inhibit enterotoxigenic Escherichia coli heat-labile enterotoxin-induced diarrhea in mice

Ginger is one of the most commonly used fresh herbs and spices. Enterotoxigenic Escherichia coli heat-labile enterotoxin (LT)-induced diarrhea is the leading cause of infant death in developing countries. In this study, we demonstrated that ginger significantly blocked the binding of LT to cell-surface receptor GM1, resulting in the inhibition of fluid accumulation in the closed ileal loops of mice. Biological-activity-guided searching for active components showed that zingerone (vanillylacetone) was the likely active constituent responsible for the antidiarrheal efficacy of ginger. Further analysis of chemically synthesized zingerone derivatives revealed that compound 31 (2-[(4-methoxybenzyl)oxy]benzoic acid) significantly suppressed LT-induced diarrhea in mice via an excellent surface complementarity with the B subunits of LT. In conclusion, our findings provide evidence that ginger and its derivatives may be effective herbal supplements for the clinical treatment of enterotoxigenic Escherichia coli diarrhea.