- Thiocarbazinic acids: Interaction of carbonoxysulphide with thiosemicarbazides - Synthesis of &β-(thiocarbamyl)thiocarbazinates and 1,3,4-oxadiazole and 1,2,4-triazole derivatives
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Interaction of carbon oxysulphide with 4-alkyl/arylthiosemicarbazides (I) in ethanol in the presence of sodium hydroxide forms sodium β-(N-alkyl/arylthiocarbamyl)thiocarbazinates (II).Benzylation of the latter (II) affords 5-alkyl/arylamino-2-benzylmercapto-1,3,4-oxadiazoles (IV), which can also be obtained by a one-pot synthesis involving the reaction of I with carbon oxysulphide in DMF in the presence of triethylamine and benzyl chloride.The syntheses of benzyl β-(N-alkyl/arylthiocarbamyl)thiocarbazinates (III) and 4-aryl-3-mercapto-1,2,4-triazolin-5-ones (VII) are also reported.Some of the compounds exhibit antibacterial activity.
- Chande, Madhukar S.,Karnik, Anil V,Inamdar, Arvind N,Damle, Shruti D
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p. 430 - 432
(2007/10/02)
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