Isatin sulfonamide analogs containing a Michael addition acceptor: A new class of caspase 3/7 inhibitors
A series of isatin sulfonamide analogs having a Michael acceptor were prepared and their potencies for inhibiting caspase-1, -3, -6, -7, and -8 were evaluated. These compounds have nanomolar potency for inhibiting the executioner caspases, caspase-3 and c
Chu, Wenhua,Rothfuss, Justin,D'Avignon, André,Zeng, Chenbo,Zhou, Dong,Hotchkiss, Richard S.,Mach, Robert H.
Novel isatin analogues, including isatin analogues comprising Michael Acceptors (IMAs) are disclosed. Further disclosed are methods of synthesis of the isatin analogues, and uses of the analogues, including inhibition of caspase-3 and caspase-7, and in vi
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(2009/04/24)
5-PYRROLIDINYLSULFONYL ISATIN DERIVATIVES
The present invention relates to novel 5-pyrrolidinylsulfonyl isatin derivatives, non-peptidyl Caspase binding Radioligands (CbRs) and CbR-transporter conjugates derived from said isatin derivatives, diagnostic compositions comprising said compounds of th
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Page/Page column 37-38
(2008/06/13)
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