Novel isatin analogues, including isatin analogues comprising Michael Acceptors (IMAs) are disclosed. Further disclosed are methods of synthesis of the isatin analogues, and uses of the analogues, including inhibition of caspase-3 and caspase-7, and in vi
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Page/Page column 14
(2009/04/24)
Isatin sulfonamide analogs containing a Michael addition acceptor: A new class of caspase 3/7 inhibitors
A series of isatin sulfonamide analogs having a Michael acceptor were prepared and their potencies for inhibiting caspase-1, -3, -6, -7, and -8 were evaluated. These compounds have nanomolar potency for inhibiting the executioner caspases, caspase-3 and c
Chu, Wenhua,Rothfuss, Justin,D'Avignon, André,Zeng, Chenbo,Zhou, Dong,Hotchkiss, Richard S.,Mach, Robert H.
p. 3751 - 3755
(2008/02/10)
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