9000-69-5 Usage
Production Methods
Pectin is obtained from the diluted acid extract from the inner
portion of the rind of citrus fruits or from apple pomace.
World Health Organization (WHO)
Pectin is a purified carbohydrate product isolated from the rinds
of citrus fruits or green apples. Its major constituent is polygalacteronic acid, and it
is almost completely digested and absorbed in the intestine. Pectin became
popular as a simple remedy for diarrhoea in the early 1900s. It does not affect the
frequency of stool or stool weight. Use of such products diverts attention away
from more important aspects of treatment, such as rehydration, proper nutrition
and in the case of cholera and dysentery, appropriate antibiotics.
Pharmaceutical Applications
present in multi-ingredient preparations for the management of
diarrhea, constipation, and obesity;it has also been used as an
emulsion stabilizer.
Experimentally, pectin has been used in gel formulations for the
oral sustained delivery of ambroxol.Pectin gel beads have been
shown to be an effective medium for controlling the release of a
drug within the gastrointestinal (GI) tract.It has also been used in
a colon-biodegradable pectin matrix with a pH-sensitive polymeric
coating, which retards the onset of drug release, overcoming the problems of pectin solubility in the upper GI tract.Amidated
pectin matrix patches have been investigated for the transdermal
delivery of chloroquine,and gelling pectin formulations for the
oral sustained delivery of paracetamol have been investigated in
situ.Pectin-based matrices with varying degrees of esterification
have been evaluated as oral controlled-release tablets. Lowmethoxy
pectins were shown to have a release rate more sensitive
to the calcium content of the formulation.Pectins have been used
as a component in the preparation of mixed polymer microsphere
systems with the intention of producing controlled drug release.
Biochem/physiol Actions
Pectin, a heterosaccharide component of terrestrial plant cell walls, is used as a substrate to identify, differentiate and characterized pectinase(s). Pectin is used to study its degradation by pectinolytic bacteria.
Safety Profile
Low toxicity by subcutaneous route. When heated to decomposition it emits acrid smoke and irritating fumes.
Safety
Pectin is used in oral pharmaceutical formulations and food
products, and is generally regarded as an essentially nontoxic and
nonirritant material.
Low toxicity by the subcutaneous route has been reported.
LD50 (mouse, SC): 6.4 g/kg
storage
Pectin is a nonreactive and stable material; it should be stored in a
cool, dry place.
Purification Methods
Dissolve the pectin in hot water to give a 1% solution, then cool, and make it to about 0.05M in HCl by addition of conc HCl, and precipitate it by pouring it slowly, with vigorous stirring into two volumes of 95% EtOH. After standing for several hours, the pectin is filtered through a nylon cloth, then redispersed in 95% EtOH and stood overnight. The precipitate is filtered off, washed with EtOH/Et2O, then Et2O and dried in air. [Rees & Walsh Angew Chem, Int Edn 16 214 1977, Rees Adv Carbohydr Chem 24 267 1969.]
Regulatory Status
GRAS listed. Accepted for use as a food additive in Europe.
Included in the FDA Inactive Ingredients Database (dental paste;
oral powders; topical pastes). Included in the Canadian List of
Acceptable Non-medicinal Ingredients. Included in nonparenteral
medicines licensed in the UK.
Check Digit Verification of cas no
The CAS Registry Mumber 9000-69-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,0 and 0 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 9000-69:
(6*9)+(5*0)+(4*0)+(3*0)+(2*6)+(1*9)=75
75 % 10 = 5
So 9000-69-5 is a valid CAS Registry Number.
InChI:InChI=1/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2
9000-69-5Relevant articles and documents
Isogenic strain line of bacterium for producing polyhydroxyalkanoate in which polyhydroxyalkanoate synthase gene is disrupted and method for producing polyhydroxyalkanoate using the same
-
, (2009/05/29)
A host-vector system which is equipped with a substrate supply system enzyme for polyhydroxyalkanoate synthase and which is suitable for evolutionary engineering modification of polyhydroxyalkanoate synthase. An isogenic strain line is produced by disrupting a polyhydroxyalkanoate synthase gene of a bacterium for producing polyhydroxyalkanoate.
Process for the recovery of tartaric acid and other products from tamarind pulp
-
, (2008/06/13)
The invention provides Potassium bitartrate, pectin, L(+) tartaric acid and fruit sugars present in tamarind pulp, which are recovered sequentially by extracting the pulp in water, concentrating and chilling the extract, filtering out potassium bitartrate, precipitating out pectin from the filtrate by addition of acetone, extracting L(+) tartaric acid selectively by complexation with tertiary amine and recovering from the amine layer by back extraction into aqueous layer in the presence of a diluent at around 70° C. followed by concentration and drying of the aqueous layer and treating the raffinate layer from solvent extraction with activated carbon, anion exchange resin, and concentrating to yield sugar containing 70% sugars.
