Triazole oxytocin antagonists: Identification of an aryloxyazetidine replacement for a biaryl substituent
A series of aryloxyazetidines, aryloxypyrrolidines and aryloxypiperidines were designed based on structural overlap with previously reported arylpyrazine Oxytocin antagonists. Similarly high levels of Oxytocin antagonism were achievable in these new serie
Brown, Alan,Brown, T. Bruce,Calabrese, Andrew,Ellis, Dave,Puhalo, Nicholas,Ralph, Michael,Watson, Lesa
scheme or table
p. 516 - 520
(2010/04/05)
A convenient synthesis of highly substituted 3-N,N-dialkylamino-1,2,4- triazoles
The title compounds are prepared from S-methylisothioureas and acyl hydrazides in moderate to good yields. The reaction is characterized by relatively mild conditions and very broad functional group tolerance. Georg Thieme Verlag Stuttgart.
Batchelor, David V.,Beal, David M.,Brown, T. Bruce,Ellis, David,Gordon, David W.,Johnson, Patrick S.,Mason, Helen J.,Ralph, Michael J.,Underwood, Toby J.,Wheeler, Simon
scheme or table
p. 2421 - 2424
(2009/04/08)
Substituted triazole derivatives as oxytocin antagonists
The present invention relates to substituted triazoles of formula (I), uses thereof, processes for the preparation thereof and compositions containing said compounds. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction.
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Page/Page column 38
(2008/06/13)
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