900512-30-3Relevant academic research and scientific papers
Triazole oxytocin antagonists: Identification of an aryloxyazetidine replacement for a biaryl substituent
Brown, Alan,Brown, T. Bruce,Calabrese, Andrew,Ellis, Dave,Puhalo, Nicholas,Ralph, Michael,Watson, Lesa
scheme or table, p. 516 - 520 (2010/04/05)
A series of aryloxyazetidines, aryloxypyrrolidines and aryloxypiperidines were designed based on structural overlap with previously reported arylpyrazine Oxytocin antagonists. Similarly high levels of Oxytocin antagonism were achievable in these new serie
A convenient synthesis of highly substituted 3-N,N-dialkylamino-1,2,4- triazoles
Batchelor, David V.,Beal, David M.,Brown, T. Bruce,Ellis, David,Gordon, David W.,Johnson, Patrick S.,Mason, Helen J.,Ralph, Michael J.,Underwood, Toby J.,Wheeler, Simon
scheme or table, p. 2421 - 2424 (2009/04/08)
The title compounds are prepared from S-methylisothioureas and acyl hydrazides in moderate to good yields. The reaction is characterized by relatively mild conditions and very broad functional group tolerance. Georg Thieme Verlag Stuttgart.
Substituted triazole derivatives as oxytocin antagonists
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Page/Page column 38, (2008/06/13)
The present invention relates to substituted triazoles of formula (I), uses thereof, processes for the preparation thereof and compositions containing said compounds. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction.
