903875-64-9Relevant articles and documents
INHIBITING HUMAN INTEGRIN α4β7
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Page/Page column 163, (2021/04/23)
Disclosed are small molecule antagonists of human α4β7 integrin, and methods of using them to treat a number of diseases and conditions.
TRICYCLIC COMPOUNDS AS HPK1 INHIBITOR AND THE USE THEREOF
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Paragraph 0101; 0102; 0103, (2021/01/29)
Disclosed herein is a tricyclic compound of Formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions comprising thereof. Also disclosed is a method of treating HPK1 related disorders or diseases by using the compound disclosed herein.
IRE1 SMALL MOLECULE INHIBITORS
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Paragraph 00271, (2018/06/22)
Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a
1,2-BENZOTHIAZOLE COMPOUNDS FOR THE TREATMENT OF KIDNEY DISORDERS
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Page/Page column 12-13, (2016/06/15)
The present invention provides 1,2-benzothiazole compounds particularly useful in the treatment of diabetic nephropathy and other chronic kidney disorders and other diabetic complications.
Pesticidal compositions and processes related thereto
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Page/Page column 140, (2016/01/09)
This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.
PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO
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Page/Page column 138, (2014/07/08)
This document discloses molecules having the following formula ("Formula One"): and processes associated therewith.
PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO
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Paragraph 0705, (2014/06/25)
This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.
PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO
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Paragraph 0870, (2014/06/25)
This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.
PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO
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Page/Page column, (2014/06/25)
This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.
Fragment-based discovery of JAK-2 inhibitors
Antonysamy, Stephen,Hirst, Gavin,Park, Frances,Sprengeler, Paul,Stappenbeck, Frank,Steensma, Ruo,Wilson, Mark,Wong, Melissa
body text, p. 279 - 282 (2009/04/16)
Fragment-based hit identification coupled with crystallographically enabled structure-based drug design was used to design potent inhibitors of JAK-2. After two iterations from fragment 1, we were able to increase potency by greater than 500-fold to provide sulfonamide 13, a 78-nM JAK-2 inhibitor.