51437-00-4

Usage

Uses

Used in Chemical Synthesis:
5-Bromo-2-fluorotoluene is used as a key intermediate in the preparation of 5-bromo-2-fluorobenzyl bromide via N-bromosuccinimide (NBS) bromination. 5-Bromo-2-fluorotoluene is essential for the synthesis of crown bromofluorobenzene and 3-(4-fuoro-3-methylphenyl)acrylamide, which are important in various chemical applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-Bromo-2-fluorotoluene is utilized as an intermediate for the synthesis of various medicinal compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications, contributing to the advancement of medical treatments.
Used in Material Science:
5-Bromo-2-fluorotoluene may also find applications in material science, particularly in the development of novel materials with specific properties. Its chemical structure can be manipulated to create new compounds with desired characteristics, such as improved stability, reactivity, or selectivity in various chemical processes.

InChI:InChI=1/C7H6BrF/c1-5-4-6(8)2-3-7(5)9/h2-4H,1H3

Upstream product

• 93777-26-5 5-bromo-2-fluorobenzaldehyde 

Downstream Products

• 135427-08-6 4-fluoro-3-methylbenzaldehyde 
• 713517-63-6 (2-amino-phenyl)-(4-fluoro-3-methyl-phenyl)-methanone 
• 870452-15-6 4-(4-fluoro-3-methylphenyl)-4-hydroxy-N-Boc-piperidine 
• 496943-59-0 4-(4-fluoro-3-methylphenyl)-1,2,3,6-tetrahydropyridine 
• 855848-94-1 3α-(4-fluoro-3-methylphenyl)tropane-2β-carboxylic acid methyl ester 
• 185147-08-4 4-fluoro-3-methylbenzonitrile 
• 1027924-56-6 2-(4-Fluoro-3-methyl-phenyl)-1-(4-methanesulfonyl-phenyl)-4-trifluoromethyl-4,5-dihydro-1H-imidazol-4-ol 
• 170638-82-1 8-(4-Fluoro-3-methyl-phenyl)-3,4-dihydro-2H-benzo[b]oxepin-5-one 
• 170639-06-2 [8-(4-Fluoro-3-methyl-phenyl)-2,3,4,5-tetrahydro-benzo[b]oxepin-5-yl]-heptyl-amine 
• 99725-13-0 (5-bromo-2-fluorophenyl)methanol 
• 99748-26-2 2-(acetoxymethyl)-4-bromo-1-fluorobenzene 
• 99725-14-1 4-bromo-1-fluoro-2-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>benzene 
• 85494-02-6 (E)-(3R,5S)-7-(4'-Fluoro-3,5,3'-trimethyl-biphenyl-2-yl)-3,5-dihydroxy-hept-6-enoic acid ((R)-1-phenyl-ethyl)-amide 
• 852415-45-3 N-(4-fluoro-3-methylphenyl)-piperidine-4-carboxylic acid methylester 

Relevant academic research and scientific papers

Indazoles: Regioselective protection and subsequent amine coupling reactions

(Chemical Equation Presented) Indazoles are unselectively protected under strongly basic conditions to give a mixture at N-1 and N-2. Under mildly acidic conditions, regioselective protection at N-2 takes place. Thermodynamic conditions lead to regioselective protection at N-1. This trend applies to various substituted indazoles. Protected 5-bromoindazoles participate in Buchwald reactions with a range of amines to generate novel derivatives.