904311-41-7

Basic information

• Product Name: 2-Pyridinecarboxylic acid, 4-aMino-6-chloro-5-cyano-
• Synonyms: 2-Pyridinecarboxylic acid, 4-aMino-6-chloro-5-cyano-;4-AMino-6-chloro-5-cyanopicolinic acid
• CAS NO: 904311-41-7
• Molecular Formula: C₇H₄ClN₃O₂
• Molecular Weight: 197.57856
• Mol File: 904311-41-7.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Pyridinecarboxylic acid, 4-aMino-6-chloro-5-cyano-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinecarboxylic acid, 4-aMino-6-chloro-5-cyano-(904311-41-7)
• EPA Substance Registry System: 2-Pyridinecarboxylic acid, 4-aMino-6-chloro-5-cyano-(904311-41-7)

Safety Data

• Hazardous Substances Data: 904311-41-7(Hazardous Substances Data)

Upstream product

• 904311-40-6 trifluoromethanesulfonic acid 4-amino-6-chloro-5-cyanopyridin-2-yl ester 
• 102291-59-8 4-amino-2-chloro-6-hydroxynicotinonitrile 
• 917102-32-0 4-amino-6-chloro-5-cyanopyridine-2-carboxylic acid methyl ester 

Downstream Products

• 904311-42-8 4-Amino-6-chloro-5-cyano-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamide 
• 904312-67-0 4-amino-3-cyano-6-(4-methanesulfonyl-benzylcarbamoyl)-pyridine-2-carboxylic acid methyl ester 
• 904312-66-9 4-amino-3-cyano-6-(4-methanesulfonyl-benzylcarbamoyl)-pyridine-2-carboxylic acid 

Relevant articles and documents

Inhibitors of c-Jun N-terminal kinases

The present invention relates to compounds that are inhibitors of c-jun N-terminal kinase 1, 2, or 3 (JNK1, JNK2, or JNK3), compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the activation of JNK1, JNK2 and JNK3.

Aminopyridine carboxamides as c-Jun N-terminal kinase inhibitors: Targeting the gatekeeper residue and beyond

The structure-activity relationships of 5,6-positions of aminopyridine carboxamide-based c-Jun N-terminal Kinase (JNK) inhibitors were explored to expand interaction with the kinase specificity and ribose-binding pockets. The syntheses of analogues and the impact of structural modification on in vitro potency and cellular activity are described.

Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors

C-Jun NH2 terminal kinases (JNKs) are important cell signaling enzymes. JNK1 plays a central role in linking obesity and insulin resistance. JNK2 and JNK3 may be involved in inflammatory and neurological disorders, respectively. Small-molecule JNK inhibitors could be valuable tools to study the therapeutic benefits of inhibiting these enzymes and as leads for potential drugs targeting JNKs. In this report, we disclose a series of potent and highly selective JNK inhibitors with good pharmacokinetic profiles.