905580-84-9

Basic information

• Product Name: (1R,2R,3S,5S)-2-Hydroxy-6-oxabicyclo[3.1.0]hexane-3-Methanol
• Synonyms: (1R,2R,3S,5S)-2-Hydroxy-6-oxabicyclo[3.1.0]hexane-3-Methanol;(1R,2R,3S,5S)-3-(hydroxyMethyl)-6-oxabicyclo[3.1.0]hexan-2-ol
• CAS NO: 905580-84-9
• Molecular Formula: C₆H₁₀O₃
• Molecular Weight: 130.1418
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 905580-84-9.mol

Chemical Properties

• Boiling Point: 291.0±10.0 °C(Predicted)
• Appearance: /
• Density: 1.383±0.06 g/cm3(Predicted)
• Solubility: Chloroform, Ethyl Acetate, Methanol
• PKA: 14.26±0.40(Predicted)
• CAS DataBase Reference: (1R,2R,3S,5S)-2-Hydroxy-6-oxabicyclo[3.1.0]hexane-3-Methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R,3S,5S)-2-Hydroxy-6-oxabicyclo[3.1.0]hexane-3-Methanol(905580-84-9)
• EPA Substance Registry System: (1R,2R,3S,5S)-2-Hydroxy-6-oxabicyclo[3.1.0]hexane-3-Methanol(905580-84-9)

Safety Data

• Hazardous Substances Data: 905580-84-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(1R,2R,3S,5S)-2-Hydroxy-6-oxabicyclo[3.1.0]hexane-3-Methanol is used as a key intermediate in the synthesis of nucleoside derivatives, which serve as inhibitors of E1 activating enzymes. These nucleoside derivatives have potential applications in the development of antiviral and anticancer drugs, as they can target and disrupt essential cellular processes in infected or cancerous cells.
In addition to its role in the pharmaceutical industry, Glycerol has a wide range of applications across various industries due to its unique properties. Some of these applications include:
Used in Food and Beverage Industry:
Glycerol is used as a humectant, sweetener, and preservative in the food and beverage industry. Its hygroscopic nature helps maintain moisture in food products, while its sweetening properties enhance the taste of various food items and beverages.
Used in Cosmetics and Personal Care Industry:
In the cosmetics and personal care industry, Glycerol is utilized as a moisturizer and emollient due to its ability to attract and retain water. It is commonly found in skincare products, hair care products, and oral care products, where it helps maintain skin and hair health.
Used in Industrial Applications:
Glycerol is used as a solvent, lubricant, and raw material in various industrial applications. It is a component of antifreeze, de-icing fluids, and hydraulic fluids. Additionally, it is used in the manufacturing of paints, inks, and resins.
Used in Energy Production:
Glycerol can be converted into biofuels, such as biodiesel and bioethanol, through various chemical and biological processes. This makes it a valuable feedstock in the production of renewable energy sources.

Upstream product

• 151765-20-7 (1S,5S)-5-hydroxymethyl-2-cyclopenten-1-ol 

Downstream Products

• 905580-85-0 (1aS,1bR,5aS,6aS)-3-(4-Methoxyphenyl)hexahydrooxireno[4,5]-cyclopenta[1,2-d][1,3]dioxine 
• 1005006-71-2 (1S,2R,3S,4S)-1-benzyloxymethyl-2-benzyloxy-3,4-epoxycyclopentane 
• 1007124-99-3 6-chloro-N-[(4aS,6R,7aS)-2-(4-methoxyphenyl)-hexahydrocyclopenta[d][1,3]dioxin-6-yl]pyrimidin-4-amine 
• 1007124-97-1 2-[(4aS,6R,7aS)-2-(4-methoxyphenyl)-hexahydrocyclopenta[d][1,3]dioxin-6-yl]-1H-isoindole-1,3(2H)-dione 
• 1007124-95-9 2-[(4aS,6R,7S,7aR)-7-hydroxy-2-(4-methoxyphenyl)-hexahydrocyclopenta[d][1,3]dioxin-6-yl]-1H-isoindole-1,3(2H)-dione 
• 1007125-99-6 N-[(1S)-2,3-Dihydro-1H-inden-1-yl]-6-{[(4aS,6S,7aS)-2-(4-methoxyphenyl)-hexahydrocyclopenta[d][1,3]dioxin-6-yl]methyl}pyrimidin-4-amine 
• 1007124-96-0 O-[(4aS,6R,7S,7aR)-6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-(4-methoxyphenyl)hexahydrocyclopenta[d][1,3]dioxin-7-yl] O-phenyl thiocarbonate 
• 1007124-98-2 (4aS,6R,7aS)-2-(4-methoxyphenyl)hexahydrocyclopenta[d][1,3]dioxin-6-amine 
• 1007125-97-4 (4aS,6S,7S,7aR)-6-({6-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-pyrimidin-4-yl}-methyl)-2-(4-methoxyphenyl)hexahydrocyclopenta[d][1,3]dioxin-7-ol 
• 1007125-98-5 O-[(4aS,6S,7S,7aR)-6-({[(1S)-2,3-dihydro-1H-inden-1-ylamino]-pyrimidin-4-yl}-methyl)-2-(4-methoxyphenyl)hexahydrocyclopenta[d][1,3]dioxin-7-yl]-O-phenyl thiocarbonate 

Relevant articles and documents

Heteroaryl compounds useful as inhibitors of E1 activating enzymes

This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.

Carbocyclic 4′-epi-formycin

Formycin is a naturally occurring biologically responsive C-nucleoside. In pursuing the design and syntheses of novel C-nucleosides, convenient access to carbocyclic C-nucleosides based on the formycin framework was a goal. One such target was carbocyclic 4′-epi-formycin (4). This compound is reported via a procedure based on an asymmetric aldol/ring closure metathesis strategy. To provide a preliminary glimpse into the biological characterization of 4 an antiviral assay was conducted. Target 4 was found to be inactive and to lack cytotoxicity to the host cells.

Inhibitors of E1 activating enzymes

This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.

INHIBITORS OF E1 ACTIVATING ENZYMES

This invention relates to compounds that inhibit El activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.