905580-85-0

Usage

Uses

Used in Pharmaceutical Industry:
(1aS,1bR,5aS,6aS)-Hexahydro-3-(4-Methoxyphenyl)-oxireno[4,5]cyclopenta[1,2-d][1,3]dioxin is used as a key intermediate in the synthesis of nucleoside derivatives, which are known for their antitumor properties. These nucleoside derivatives have the potential to be developed into effective cancer treatments.
Used in Enzyme Research:
(1aS,1bR,5aS,6aS)-Hexahydro-3-(4-Methoxyphenyl)-oxireno[4,5]cyclopenta[1,2-d][1,3]dioxin is also utilized in the preparation of E1 activating enzymes, which play a crucial role in various cellular processes. E1 enzymes are involved in the activation of ubiquitin, a small protein that regulates protein degradation and has implications in numerous diseases, including cancer and neurodegenerative disorders.
Used in Drug Development:
Furthermore, (1aS,1bR,5aS,6aS)-Hexahydro-3-(4-Methoxyphenyl)-oxireno[4,5]cyclopenta[1,2-d][1,3]dioxin is used in the development of MLN4924, a specific inhibitor of NEDD8-activating enzyme. This enzyme is essential for the conjugation of NEDD8, a ubiquitin-like protein, to target proteins. Inhibition of this enzyme can lead to the disruption of protein homeostasis and has potential applications in the treatment of various diseases, including cancer.

Upstream product

• 905580-84-9 (1R,2R,3S,5S)-3-(Hydroxymethyl)-6-oxabicyclo[3.1.0]hexan-2-ol 
• 2186-92-7 p-Anisaldehyde dimethyl acetal 
• 151765-20-7 (1S,5S)-5-hydroxymethyl-2-cyclopenten-1-ol 

Downstream Products

• 905580-87-2 (4aS,6R,7S,7aR)-6-{4-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-7H-pyrrolo[2,3-d]-pyrimidin-7-yl}-2-(4-methoxyphenyl)hexahydrocyclopenta[d][1,3]dioxin-7-ol 
• 945950-11-8 (4aS,6R,7S,7aR)-6-[4-(Benzylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-(4-methoxyphenyl)hexahydrocyclopenta[d][1,3]dioxin-7-ol 
• 945950-18-5 (4aS,6R,7S,7aR)-2-(4-methoxyphenyl)-6-[4-(phenylsulfanyl)-1H-pyrrolo[2,3-d]pyrimidin-1-yl]hexahydrocyclopenta[d][1,3]dioxin-7-ol 
• 1007125-98-5 O-[(4aS,6S,7S,7aR)-6-({[(1S)-2,3-dihydro-1H-inden-1-ylamino]-pyrimidin-4-yl}-methyl)-2-(4-methoxyphenyl)hexahydrocyclopenta[d][1,3]dioxin-7-yl]-O-phenyl thiocarbonate 
• 1007124-98-2 (4aS,6R,7aS)-2-(4-methoxyphenyl)hexahydrocyclopenta[d][1,3]dioxin-6-amine 
• 1007124-96-0 O-[(4aS,6R,7S,7aR)-6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-(4-methoxyphenyl)hexahydrocyclopenta[d][1,3]dioxin-7-yl] O-phenyl thiocarbonate 
• 1007125-99-6 N-[(1S)-2,3-Dihydro-1H-inden-1-yl]-6-{[(4aS,6S,7aS)-2-(4-methoxyphenyl)-hexahydrocyclopenta[d][1,3]dioxin-6-yl]methyl}pyrimidin-4-amine 
• 1007124-97-1 2-[(4aS,6R,7aS)-2-(4-methoxyphenyl)-hexahydrocyclopenta[d][1,3]dioxin-6-yl]-1H-isoindole-1,3(2H)-dione 
• 1007124-99-3 6-chloro-N-[(4aS,6R,7aS)-2-(4-methoxyphenyl)-hexahydrocyclopenta[d][1,3]dioxin-6-yl]pyrimidin-4-amine 
• 1007125-97-4 (4aS,6S,7S,7aR)-6-({6-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-pyrimidin-4-yl}-methyl)-2-(4-methoxyphenyl)hexahydrocyclopenta[d][1,3]dioxin-7-ol 
• 1007124-95-9 2-[(4aS,6R,7S,7aR)-7-hydroxy-2-(4-methoxyphenyl)-hexahydrocyclopenta[d][1,3]dioxin-6-yl]-1H-isoindole-1,3(2H)-dione 

Relevant academic research and scientific papers

Heteroaryl compounds useful as inhibitors of E1 activating enzymes

This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.

Inhibitors of E1 activating enzymes

This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.

INHIBITORS OF E1 ACTIVATING ENZYMES

This invention relates to compounds that inhibit El activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.