905580-86-1 Usage
Uses
Used in Pharmaceutical Industry:
N-[(1S)-2,3-dihydro-1H-inden-1-yl]-1H-pyrrolo[2,3-d]pyriMidin-4-aMine is used as a key intermediate in the synthesis of nucleoside derivatives, which are known for their antitumor properties. These nucleoside derivatives can be further modified to develop more effective and targeted cancer therapies.
Used in Enzyme Activation:
N-[(1S)-2,3-dihydro-1H-inden-1-yl]-1H-pyrrolo[2,3-d]pyriMidin-4-aMine is also utilized in the activation of enzymes, specifically E1 enzymes, which play a crucial role in various cellular processes. By enhancing the activity of these enzymes, it can contribute to the development of novel therapeutic strategies for various diseases.
Used in Inhibitor Development:
Furthermore, N-[(1S)-2,3-dihydro-1H-inden-1-yl]-1H-pyrrolo[2,3-d]pyriMidin-4-aMine is employed in the development of MLN4924, an inhibitor of NEDD8-activating enzyme. This inhibitor has potential applications in the treatment of cancer by targeting specific cellular pathways and disrupting the growth and proliferation of cancer cells.
Check Digit Verification of cas no
The CAS Registry Mumber 905580-86-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,0,5,5,8 and 0 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 905580-86:
(8*9)+(7*0)+(6*5)+(5*5)+(4*8)+(3*0)+(2*8)+(1*6)=181
181 % 10 = 1
So 905580-86-1 is a valid CAS Registry Number.
905580-86-1Relevant articles and documents
Inhibitors of E1 activating enzymes
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Page/Page column 51, (2010/11/28)
This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
INHIBITORS OF E1 ACTIVATING ENZYMES
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Page/Page column 137, (2008/06/13)
This invention relates to compounds that inhibit El activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
