905580-87-2 Usage
Uses
Used in Pharmaceutical Industry:
(4aS,6R,7S,7aR)-6-[4-[[(1S)-2,3-Dihydro-1H-inden-1-yl]aMino]-7H-pyrrolo[2,3-d]pyriMidin-7-yl]hexahydro-2-(4-Methoxyphenyl)-cyclopenta-1,3-dioxin-7-ol is used as a key intermediate in the synthesis of nucleoside derivatives. These nucleoside derivatives have potential applications as antitumor agents, making (4aS,6R,7S,7aR)-6-[4-[[(1S)-2,3-Dihydro-1H-inden-1-yl]aMino]-7H-pyrrolo[2,3-d]pyriMidin-7-yl]hexahydro-2-(4-Methoxyphenyl)-cyclopenta-1,3-dioxin-7-ol an important building block in the development of novel cancer therapies.
Used in Biochemical Research:
In the field of biochemical research, (4aS,6R,7S,7aR)-6-[4-[[(1S)-2,3-Dihydro-1H-inden-1-yl]aMino]-7H-pyrrolo[2,3-d]pyriMidin-7-yl]hexahydro-2-(4-Methoxyphenyl)-cyclopenta-1,3-dioxin-7-ol is utilized for the preparation of E1 activating enzymes. E1 enzymes play a crucial role in the ubiquitin-proteasome system, which is involved in the regulation of various cellular processes, including protein degradation and cell cycle control. The development of E1 activating enzymes can contribute to a better understanding of these processes and may lead to the discovery of new therapeutic targets for various diseases.
Used in Drug Development:
(4aS,6R,7S,7aR)-6-[4-[[(1S)-2,3-Dihydro-1H-inden-1-yl]aMino]-7H-pyrrolo[2,3-d]pyriMidin-7-yl]hexahydro-2-(4-Methoxyphenyl)-cyclopenta-1,3-dioxin-7-ol is also used in the development of MLN4924, a specific inhibitor of the NEDD8-activating enzyme. NEDD8 is a ubiquitin-like protein that is involved in the regulation of the cell cycle and the stress response. Inhibition of the NEDD8-activating enzyme by MLN4924 has been shown to induce cell cycle arrest and apoptosis in cancer cells, making it a promising candidate for the treatment of various types of cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 905580-87-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,0,5,5,8 and 0 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 905580-87:
(8*9)+(7*0)+(6*5)+(5*5)+(4*8)+(3*0)+(2*8)+(1*7)=182
182 % 10 = 2
So 905580-87-2 is a valid CAS Registry Number.
905580-87-2Relevant academic research and scientific papers
Inhibitors of E1 activating enzymes
-
Page/Page column 51-52, (2010/11/28)
This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
INHIBITORS OF E1 ACTIVATING ENZYMES
-
Page/Page column 137, (2008/06/13)
This invention relates to compounds that inhibit El activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
