- 7-SUBSTITUTED INDIRUBIN-3'OXIMES AND THEIR APPLICATIONS
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The invention relates to new 3′-, 7-substituted-indirubins of formula (I) wherein R represents N—OH, N—O-alkyl or N—O—CO-alkyl, NO—(Ra)n1-Het, N—O—(Y)n1—NRaRb, N—O—CO—N(RbRc), ra
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Page/Page column 5
(2011/01/05)
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- 3′-substituted 7-halogenoindirubins, a new class of cell death inducing agents
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Indirubins are kinase inhibitory bis-indoles that can be generated from various plant, mollusk, mammalian, and bacterial sources or chemically synthesized. We here report on the synthesis and biological evaluation of 3′-substituted 7-halogenoindirubins. M
- Ferandin, Yoan,Bettayeb, Karima,Kritsanida, Marina,Lozach, Olivier,Polychronopoulos, Panagiotis,Magiatis, Prokopios,Skaltsounis, Alexios-Leandros,Meijer, Laurent
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p. 4638 - 4649
(2007/10/03)
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