907195-92-0Relevant articles and documents
Combined Proteomic and In Silico Target Identification Reveal a Role for 5-Lipoxygenase in Developmental Signaling Pathways
Brand, Silke,Roy, Sayantani,Schr?der, Peter,Rathmer, Bernd,Roos, Jessica,Kapoor, Shobhna,Patil, Sumersing,Pommerenke, Claudia,Maier, Thorsten,Janning, Petra,Eberth, Sonja,Steinhilber, Dieter,Schade, Dennis,Schneider, Gisbert,Kumar, Kamal,Ziegler, Slava,Waldmann, Herbert
, p. 1095 - 23,1106 (2018/06/11)
Identification and validation of the targets of bioactive small molecules identified in cell-based screening is challenging and often meets with failure, calling for the development of new methodology. We demonstrate that a combination of chemical proteom
Neuritogenic Militarinone-Inspired 4-Hydroxypyridones Target the Stress Pathway Kinase MAP4K4
Schr?der, Peter,F?rster, Tim,Kleine, Stefan,Becker, Christian,Richters, André,Ziegler, Slava,Rauh, Daniel,Kumar, Kamal,Waldmann, Herbert
, p. 12398 - 12403 (2015/10/12)
Progressive loss and impaired restoration of neuronal activity are hallmarks of neurological diseases, and new small molecules with neurotrophic activity are in high demand. The militarinone alkaloids and structurally simplified analogues with 4-hydroxy-2
Hydroxyl radical-induced oxidation of a phenolic c-linked 2′-deoxyguanosine adduct yields a reactive catechol
Witham, Aaron A.,Beach, Daniel G.,Gabryelski, Wojciech,Manderville, Richard A.
scheme or table, p. 315 - 325 (2012/06/30)
Phenolic toxins stimulate oxidative stress and generate Clinked adducts at the C8-site of 2/-deoxyguanosine (dG). We previously reported that the C-linked adduct 8-(4″-hydroxyphenyl)-dG (p-PhOH-dG) undergoes oxidation in the presence of Na2IrCl
Asymmetric catalysis of intramolecular cyclopropanation of 5-aryl-1-diazo-1-mesitylsulfonyl-5-hexen-2-ones
Sawada, Takashi,Nakada, Masahisa
, p. 1527 - 1532 (2007/10/03)
We have examined the catalytic asymmetric intramolecular cyclopropanation (IMCP) reactions of 5-aryl-1-diazo-1-mesitylsulfonyl-5-hexen-2-ones, and found that the substituent of the 5-aryl group dramatically changes the enantioselectivity. That is, no enantioselectivity was observed when the substituent was a methoxy group; however, enantioselectivity was moderate when the substituent was a methylenedioxy group or a tert-butyldimethylsilyloxy group, and it dramatically increased when the substituent was lacking (96% ee) or a benzoyloxy group (93% ee).