90766-47-5

Basic information

• Product Name: AKOS JY2082718
• Synonyms: AKOS JY2082718;5-Bromo-2-carboxy-1-methyl-1H-indole
• CAS NO: 90766-47-5
• Molecular Formula: C₁₀H₈BrNO₂
• Molecular Weight: 254.08
• Mol File: 90766-47-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: AKOS JY2082718(CAS DataBase Reference)
• NIST Chemistry Reference: AKOS JY2082718(90766-47-5)
• EPA Substance Registry System: AKOS JY2082718(90766-47-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 90766-47-5(Hazardous Substances Data)

Upstream product

• 210345-56-5 5-bromo-1H-indole-2-carboxylic acid methyl ester 
• 7254-19-5 5-bromo-2-indolecarboxylic acid 
• 91844-20-1 5-bromo-1-methyl-1H-indole-2-carboxylic acid ethyl ester 
• 860457-91-6 methyl 5-bromo-1-methyl-1H-indole-2-carboxylate 

Downstream Products

• 1247826-15-8 methyl 2-{[(5-bromo-1-methyl-1H-indol-2-yl)carbonyl]amino}-5-chlorobenzoate 

Relevant articles and documents

Calcium-Catalyzed Formal [5 + 2] Cycloadditions of Alkylidene β-Ketoesters with Olefins: Chemodivergent Synthesis of Highly Functionalized Cyclohepta[ b]indole Derivatives

The calcium-catalyzed, formal [5 + 2] cycloaddition of indolyl alkylidene β-ketoesters with mono- A nd disubstituted aryl olefins to form cyclohepta[b]indole derivatives has been established. Unanticipated chemodivergence with phenyl vinyl sulfide/ether revealed a double [5 + 2] cycloaddition cascade providing ethano-bridged cyclohepta[b]indoles. Overall, the method's highlights include: (1) use of a green, calcium-based catalyst (2.5 mol % loading); (2) reaction times under 1 h; (3) mild reaction conditions; (4) substrate-derived chemodivergence; (5) functional group tolerance; and (6) examples of derivatization.

Copper-catalyzed intermolecular C-H amination of (Hetero)arenes via transient unsymmetrical λ3-iodanes

A one-pot two-step method for intermolecular C-H amination of electron-rich heteroarenes and arenes has been developed. The approach is based on a room-temperature copper-catalyzed regioselective reaction of the in situ formed unsymmetrical (hetero)aryl-λ3-iodanes with a wide range of primary and secondary aliphatic amines and anilines.

Vanilloid receptor ligands and their use in treatments

Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.