- Heterocyclic Betaines. 14. (E)-1-Alkyl-dihydropyridines with a Betaine Character. An Improved Protocol for a Knoevenagel-Type Condensation for Synthesis of (E)-1-Alkyl-pyridinium Salts
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A novel class of aza analogues of (E)-stilbene, the (E)-1-alkyl-dihydropyridines 4A 4B, 5A 5B, have been studied.They were synthesized by a convenient two-steps procedure.In each of the steps, the necessary basic reaction medium has been generated by a strong basic ion-exchange resin (OH(-)-form).Thus, a modified protocol of the Knoevenagel condensation has been applied to preparation of the title (imidazolylvinyl)pyridinium salts, deprotonation of which yields several examples of compounds 4 and 5.The betaine character of 4 and 5 is well reflected by their physicochemical properties and reactivity toward electrophiles (MeI).
- Alcalde, Ermitas,Roca, Tomas
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- RECYCLIZATION OF PYRIDINIUM SALTS WITH EXCHANGE AS A METHOD FOR THE PREPARATION OF N-SUBSTITUTED AROMATIC AMINES
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The conditions for the formation of N-substituted aromatic amines in the sulfite variant of recyclization of pyridinium salts, as well as the structural factors that affect the yield of the final substances, were investigated.
- Shkil', G. P.,Khristolyubova, O. V.,Lugovik, B. A.,Atavin, E. G.,Sagitullin, R. S.
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p. 914 - 917
(2007/10/02)
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