908009-54-1

Basic information

• Product Name: 1-Chloro-5-fluoro-4-nitro-2-(trichloromethyl)benzene
• Synonyms: 1-Chloro-5-fluoro-4-nitro-2-(trichloromethyl)benzene;1-Chloro-5-fluoro-4-nitro-2-(trichloromethyl)benzene, 4-Chloro-2-fluoro-5-(trichloromethyl)nitrobenzene;2-Chloro-4-fluoro-5-nitrobenzotrichloride
• CAS NO: 908009-54-1
• Molecular Formula: C₇H₂Cl₄FNO₂
• Molecular Weight: 292.9066832
• Mol File: 908009-54-1.mol

Chemical Properties

• Boiling Point: 333.1±37.0 °C(Predicted)
• Appearance: /
• Density: 1.735±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Chloro-5-fluoro-4-nitro-2-(trichloromethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Chloro-5-fluoro-4-nitro-2-(trichloromethyl)benzene(908009-54-1)
• EPA Substance Registry System: 1-Chloro-5-fluoro-4-nitro-2-(trichloromethyl)benzene(908009-54-1)

Safety Data

• Hazardous Substances Data: 908009-54-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
1-Chloro-5-fluoro-4-nitro-2-(trichloromethyl)benzene is used as an intermediate in the synthesis of pharmaceuticals for its unique combination of halogenated and nitro groups, which can be further modified to create various medicinal compounds.
Used in Agrochemical Synthesis:
In the agrochemical industry, 1-Chloro-5-fluoro-4-nitro-2-(trichloromethyl)benzene is used as an intermediate in the production of pesticides and herbicides, leveraging its reactivity and potential bioactivity to control or eliminate unwanted plant species.

InChI:InChI=1S/C7H2Cl4FNO2/c8-4-2-5(12)6(13(14)15)1-3(4)7(9,10)11/h1-2H

Upstream product

• 88578-92-1 2-chloro-4-fluoro-benzotrichloride 

Downstream Products

• 120890-66-6 2-chloro-4-fluoro-5-nitrobenzoyl chloride 
• 114776-15-7 2-chloro-4-fluoro-5-nitrobenzoic acid 

Relevant articles and documents

Method for efficient synthesis of 2-chloro-4-fluoro-5-nitrotrichlorotoluene

The invention discloses a method for efficient synthesis of 2-chloro-4-fluoro-5-nitrotrichlorotoluene. The method comprises the following steps of (1) a nitrification reaction, wherein concentration sulfuric acid with the mass concentration of 98% and concentrated nitric acid with the mass concentration of 98 % are mixed according to the mass ratio of 1:1 to prepare mixed acid, and 2-chloro-4-fluorotrichlorotoluene is added dropwise into the mixed acid under the condition of stirring to carry out the nitration reaction; (2) quenching of the reaction, wherein a nitrified material obtained afterthe nitrification reaction is put into an ice-water mixture for stirring to quench the reaction; (3) preparation of a dry product, wherein after the reaction is quenched, a circulating water vacuum pump is adopted for suction filtration, and then washing and drying are conducted to obtain the dry product of 2-chloro-4-fluoro-5-nitrotrichlorotoluene; (4) recycling, wherein a filtrate obtained after the suction filtration and washing water are recovered for recycling. The method can improve the production efficiency, the color of the finished product is pure, and the yield and purity of the product are also high and are both 90% or above.

PROCESS FOR THE PREPARATION OF 2-CHLORO-4-FLUORO-5-NITROBENZOTRICHLORIDE

The present invention relates to an improved process for the preparation of 2-chloro-4-fluoro-5-nitrobenzotrichloride. The present invention further relates to a process for the purification of 2-chloro-4-fluoro-5-nitrobenzotrichloride, which reduces the isomeric impurities and acidic by-products.

PROCESS FOR THE PREPARATION OF BENZOIC ACID DERIVATIVES VIA A NEW INTERMEDIATE OF SYNTHESIS

The object of the invention is the preparation of 2-chloro-4-fluoro-5-nitrobenzoic acid and derivatives thereof, by nitration of 2-chloro-4-fuorobenzotrichloride and the conversion of the novel synthetic intermediate thus obtained into its acid form or de