114776-15-7

Usage

Uses

2-Chloro-4-fluoro-5-nitrobenzoic acid is used as pharmaceutical intermediate.

InChI:InChI=1/C7H3ClFNO4/c8-4-2-5(9)6(10(13)14)1-3(4)7(11)12/h1-2H,(H,11,12)

Upstream product

• 2252-51-9 2-choro-4-fluorobenzoic acid 
• 452-73-3 2-chloro-4-fluorotoluene 
• 908009-54-1 2-chloro-4-fluoro-5-nitro-benzotrichloride 

Downstream Products

• 101329-81-1 2-chloro-4-fluoro-5-nitrobenzenemethanol 
• 120890-66-6 2-chloro-4-fluoro-5-nitrobenzoyl chloride 
• 188490-53-1 ethyl 2-chloro-4-fluoro-5-nitrobenzoate 
• 134605-95-1 2-chloro-4-fluoro-5-nitrobenzoic acid(1-methyl-1-ethoxycarbonyl)ethyl ester 
• 1032903-53-9 2-chloro-4-isopropoxy-5-nitro-benzoic acid 
• 33458-99-0 2-chloro-4-methoxy-5-nitrobenzoic acid 
• 783357-48-2 3-(2-chloro-4-fluoro-5-nitrophenyl)-3-oxopropionic acid ethyl ester 
• 1256969-14-8 2-(4-chloro-2-((tetrahydropyran-4-yl)amino)nitrobenzen-5-yl)benzoxazole 
• 1380836-76-9 methyl 2-chloro-4-(methylamino)-5-nitrobenzoate 
• 110322-88-8 2'-chloro-4'-fluoro-5'-nitroacetophenone 
• 1402890-90-7 methyl 2-(2-chloro-4-fluoro-5-nitrophenyl)-2-hydroxyacetate 
• 1402890-91-8 methyl 2-(tert-butoxy)-2-(2-chloro-4-fluoro-5-nitrophenyl)acetate 
• 1402890-92-9 methyl 2-(tert butoxy)-2-(2-chloro-5-nitro-4-phenoxyphenyl)acetate 
• 1402890-93-0 methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-nitro-4-phenoxyphenyl]acetate 

Relevant academic research and scientific papers

For the treatment of tumor macrocyclic derivatives (by machine translation)

The invention discloses a method for modulating protein kinase activity, and is used for the treatment or prevention of protein kinase related disorders. Specifically, the invention relates to a method for the treatment of tumor of the macrocyclic derivatives, which belongs to the regulating Anaplastic lymphoma kinase (ALK) active compound, and provides the preparation method of the compound, and the compound used for the treatment or prevention of diseases associated with the ALK pharmaceutical use. (by machine translation)

Synthesis method of 2-chloride-4-fluoride-5-nitrobenzoic acid

The invention relates to a synthesis method of 2-chloride-4-fluoride-5-nitrobenzoic acid. The synthesis method is characterized by including the steps: adding 2-chloride-4 fluorobenzoic acid and a catalyst into concentrated sulfuric acid; dripping nitroso

BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE

Novel benzamide derivatives of formula (I) wherein W1, W2, R1 to R10 and X have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.

Inhibitors of viral replication, their process of preparation and their therapeutical uses

The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.

INHIBITORS OF VIRAL REPLICATION, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES

The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.

PROCESS FOR THE PREPARATION OF BENZOIC ACID DERIVATIVES VIA A NEW INTERMEDIATE OF SYNTHESIS

The object of the invention is the preparation of 2-chloro-4-fluoro-5-nitrobenzoic acid and derivatives thereof, by nitration of 2-chloro-4-fuorobenzotrichloride and the conversion of the novel synthetic intermediate thus obtained into its acid form or de

HETEROARYL DERIVATIVES AS PROTEIN KINASE INHIBITORS

Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS AURORA KINASE INHIBITORS

The present invention relates to compounds and methods from the treatment of cancer. The invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising compounds that inhibit Aurora kinase, and methods for the treatment of cancer using the compounds of the presentation invention or pharmaceutical compositions comprising compounds of the present invention.

New 6-nitroquinolones: Synthesis and antimicrobial activities

Pursuing our searches on quinolonecarboxylic acids we used a simple three-step one pot procedure to synthesize novel 1,7-disubstituted-6- nitroquinolones. The new derivatives were tested against Mycobacterium tuberculosis and Mycobacterium avium complex (

Uracil substituted phenyl sulfamoyl carboxamides

Novel uracil substituted phenyl sulfamoyl carboxamides I and salts thereof, where A=oxygen or sulfur; X1=H, halogen, C1-C4-alkyl; X2=H, CN, CS—NH2, halogen, C1-C4-alkyl, C1-C4-haloalkyl; X3=H, CN, C1-C6-alkyl, C1-C6-alkoxyalkyl, C3-C7-cycloalkyl, C3-C6-alkenyl, C3-C6-alkynyl, optionally substituted benzyl; R1, R2=H, halogen, optionally substituted hydroxy, C1-C10-alkyl, C2-C10-alkenyl, C3-C10-alkynyl, C3-C7-cycloalkyl, phenyl, benzyl or C5-C7-cycloalkenyl, or R1+R2 together with the atom to which they are attached form a 3- to 7-membered heterocyclic ring; Q is selected from Q1 to Q40 as defined in the description. Use: As herbicides; for the desiccation/defoliation of plants.