90915-65-4

Basic information

• Product Name: METHYL 5-METHOXY-1H-INDAZOLE-3-CARBOXYLATE
• Synonyms: METHYL 5-METHOXY-1H-INDAZOLE-3-CARBOXYLATE;1H-Indazole-3-carboxylic acid, 5-Methoxy-, Methyl ester;5-Methoxy-1H-indazole-3-carboxylic acid Methyl ester
• CAS NO: 90915-65-4
• Molecular Formula: C10H10N2O3
• Molecular Weight: 206.2
• Mol File: 90915-65-4.mol

Chemical Properties

• Boiling Point: 382.235 °C at 760 mmHg
• Flash Point: 184.969 °C
• Appearance: /
• Density: 1.313 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.619
• Storage Temp.: 2-8°C
• CAS DataBase Reference: METHYL 5-METHOXY-1H-INDAZOLE-3-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 5-METHOXY-1H-INDAZOLE-3-CARBOXYLATE(90915-65-4)
• EPA Substance Registry System: METHYL 5-METHOXY-1H-INDAZOLE-3-CARBOXYLATE(90915-65-4)

Safety Data

• Hazardous Substances Data: 90915-65-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 5-METHOXY-1H-INDAZOLE-3-CARBOXYLATE is used as a building block for the synthesis of novel drug candidates, contributing to the development of new pharmaceuticals that address various biological processes and medical conditions.
Used in Research and Development:
In the realm of pharmaceutical research and development, METHYL 5-METHOXY-1H-INDAZOLE-3-CARBOXYLATE is utilized for the exploration and creation of new chemical entities with potential therapeutic applications.
Used in Agrochemicals:
Due to its unique chemical properties, METHYL 5-METHOXY-1H-INDAZOLE-3-CARBOXYLATE has potential applications in the agrochemical industry, where it may be employed in the development of new compounds for agricultural use.
Used in Materials Science:
Its distinctive chemical characteristics also position METHYL 5-METHOXY-1H-INDAZOLE-3-CARBOXYLATE as a candidate for use in materials science, potentially leading to advancements in the synthesis of complex organic molecules and other material innovations.

InChI:InChI=1/C10H10N2O3/c1-14-6-3-4-8-7(5-6)9(12-11-8)10(13)15-2/h3-5H,1-2H3,(H,11,12)

Upstream product

• 67-56-1 methanol 
• 90417-53-1 5-methoxy-1H-indazole-3-carboxylic acid 
• 201230-82-2 carbon monoxide 
• 290367-99-6 3-iodo-5-methoxy-1H-indazole 
• 39755-95-8 5-methoxyisatine 

Downstream Products

• 1029643-79-5 5-methoxy-2-methyl-2H-indazole-3-carboxylic acid methyl ester 
• 169789-36-0 5-methoxy-1H-indazole-3-methanol 
• 169789-37-1 5-methoxy-1H-indazole-3-carboxaldehyde 

Relevant articles and documents

ALKYNYL ALCOHOLS AND METHODS OF USE

The invention relates to compounds of Formula (0): wherein Q, A1-A8, R4 and R5 and each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over- activation of NF-kB signaling is observed.

ANTICANCER AGENT

An anticancer agent comprising a compound represented by the formula (I) [R1 represents hydrogen atom, hydroxyl group, a C1-6alkoxy group and the like; R2 and R3 represents hydrogen atom, a halogen atom, a C1-6alkyl group and the like; R4 represents hydrogen atom, a C1-6alkyl group, a C1-6alkylsulfonyl group and the like; R5 represents hydrogen atom or a substituent; .... represents a single bond or a double bond; R6 and R7 represents hydrogen atom, a C1-6alkyl group and the like; R8 represents hydrogen atom, a C1-6alkyl group and the like; A represents -O-, -S-, or - CH2-; D represents -C= or -N=; X represents methylene group, -O-, or -CO-; Q represents -N= or -C(R8)=; and Y represents a heterocyclic group or amino group], which shows a superior inhibitory activity against pim-1 kinase.

Synthesis of 3-indazolecarboxylic esters and amides via Pd-catalyzed carbonylation of 3-iodoindazoles

A straightforward and effective procedure for the preparation of 1H-indazole-3-carboxylic acid esters and amides was developed. A series of functionalized 3-iodoindazoles were subjected to Pd-catalyzed carbonylations in the presence of methanol or amines,

2 -ALKYL- INDAZOLE COMPOUNDS FOR THE TREATMENT OF CERTAIN CNS-RELATED DISORDERS

2-Alkyl-indazole compound and its pharmaceutically acceptable salts of acid addition, method and intermediates for preparing them, a pharmaceutical composition containing them and use of the latter. The 2-alkyl-indazole compound has the following general formula (I) in which R1, R2, R3, R4, R6, R7, X, Y, W, n, p, and m have the meanings stated in the description.

CONDENSED PYRAZOLE DERIVATIVES AS PPAR AGONISTS II

The invention discloses compounds of formula (I) wherein: R is a carboxylic acid or a derivative thereof; R1 and R2 are independently H or alkyl, or together R1 and R2 form an alkylene group; L1 is a